Modular and stereoselective formal synthesis of MeBmt, an unusual amino acid constituent of cyclosporin A

被引：4

作者：

Raghavan, S ^{[1
]}

Rasheed, MA ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Organ Div 1, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON | 2004年 / 60卷 / 13期

关键词：

MeBmt; sulfoxide; neighbouring group participation; bromohydrin;

D O I：

10.1016/j.tet.2004.01.088

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent, flexible and stereoselective formal synthesis of MeBmt, the nonproteinogenic amino acid constituent of cyclosporin A is disclosed. The sulfinyl moiety has been exploited as the internal nucleophile to stereo- and regioselectively functionalize, an allylic carbamate. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3059 / 3065

页数：7

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