Comparison of whole body positron emission tomography (PET)/PET-computed tomography and conventional anatomic imaging for detecting distant malignancies in patients with head and neck cancer: A meta-analysis

被引:27
|
作者
Xu, Guozeng [1 ,2 ,3 ]
Li, Junkai [1 ,2 ,4 ]
Zuo, Xiaoyan [4 ]
Li, Chunyan [1 ,2 ]
机构
[1] Guangxi Med Univ, Affiliated Hosp 1, Dept Radiol, Nanning 530021, Peoples R China
[2] Guangxi Med Univ, Affiliated Hosp 1, Evidence Based Med Ctr, Nanning 530021, Peoples R China
[3] Guangxi Zhuang Autonomous Reg Tumor Hosp, Dept Radiat Oncol, Nanning, Peoples R China
[4] 456 Hosp Peoples Liberat Army, Dept Clin Oncol, Jinan, Peoples R China
来源
LARYNGOSCOPE | 2012年 / 122卷 / 09期
关键词
Head and neck neoplasms; whole body positron emission tomography; distant malignancies; meta-analysis; METASTASES; TUMORS; OROPHARYNGEAL; SPECIFICITY; SENSITIVITY; CARCINOMAS; PET;
D O I
10.1002/lary.23409
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Objectives/Hypothesis: We aimed to compare the accuracy of whole body positron emission tomography (PET)/PET-computed tomography (CT) and conventional anatomic imaging for detecting distant malignancies in patients with head and neck cancer. Study Design: Meta-Analysis. Methods: We performed a meta-analysis of all available studies. We compared the performance of whole body PET/PET-CT with that of conventional anatomic imaging by analyzing studies that had also used conventional anatomic imaging on the same patients. Results: Across eight studies (1,147 patients), sensitivity and specificity of PET/PET-CT were 0.83 (95% confidence interval [CI], 0.760.88) and 0.96 (95% CI, 0.940.97), respectively, and for conventional anatomic imaging were 0.44 (95% CI, 0.290.61) and 0.96 (95% CI, 0.880.98), respectively. Subgroup analysis showed that PET/PET-CT had higher sensitivity than conventional anatomic imaging for nasopharyngeal cancer (0.82 vs. 0.30) and non-nasopharyngeal head and neck cancer (0.85 vs. 0.62). Conclusions: Compared with conventional anatomic imaging, whole body PET/PET-CT has excellent diagnostic performance for detecting distant malignancies in patients with head and neck cancer.
引用
收藏
页码:1974 / 1978
页数:5
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