Real-time mechanistic monitoring of an acetal hydrolysis using ultrafast 2D NMR

被引：29
|
作者：
Queiroz, Luiz H. K., Jr. [1 ,2 ]
Giraudeau, Patrick [3 ]
dos Santos, Fabiane A. B. [1 ]
de Oliveira, Kleber T. [1 ]
Ferreira, Antonio G. [1 ]
机构：
[1] Univ Fed Sao Carlos UFSCar, Dept Quim, Lab Ressonancia Magnet Nucl, BR-13565905 Sao Carlos, SP, Brazil
[2] Univ Fed Goias, Inst Quim, Lab Ressonancia Magnet Nucl, Goiania, Go, Brazil
[3] Univ Nantes, CNRS, UMR 6230, Nantes, France
来源：
MAGNETIC RESONANCE IN CHEMISTRY | 2012年 / 50卷 / 07期
基金：
巴西圣保罗研究基金会;
关键词：
NMR; 1H; 13C; ultrafast NMR; NMR theoretical calculations; acetal hydrolysis; hemiacetal intermediate; SPECTROSCOPY; SENSITIVITY;
D O I：
10.1002/mrc.3827
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Ultrafast (UF) 2D NMR makes it possible to obtain a 2D NMR spectrum in less than a second. Here, UF-HSQC experiments are used for the real-time mechanistic study of an acetal hydrolysis at C-13 natural abundance, and it is possible to characterize the presence of the hemiacetal, an intermediate with a well-known short lifetime. The assignments are confirmed and rationalized by quantum calculations of H-1 and C-13 NMR chemical shifts and natural bonding orbital analysis. Copyright (c) 2012 John Wiley & Sons, Ltd.
引用
收藏
页码：496 / 501
页数：6
相关论文
共 50 条
  • [21] Ultrafast 2D NMR: Methods and Applications
    Gouilleux, Boris
    Rouger, Laetitia
    Giraudeau, Patrick
    ANNUAL REPORTS ON NMR SPECTROSCOPY, VOL 93, 2018, 93 : 75 - 144
  • [22] Animating 3D Vegetation in Real-time Using a 2D Approach
    Chen, Kan
    Johan, Henry
    PROCEEDINGS - I3D 2015, 2015, : 69 - 76
  • [23] Time- and site-resolved kinetic NMR for real-time monitoring of off-equilibrium reactions by 2D spectrotemporal correlations
    Jaroszewicz, Michael J.
    Liu, Mengxiao
    Kim, Jihyun
    Zhang, Guannan
    Kim, Yaewon
    Hilty, Christian
    Frydman, Lucio
    NATURE COMMUNICATIONS, 2022, 13 (01)
  • [24] Time- and site-resolved kinetic NMR for real-time monitoring of off-equilibrium reactions by 2D spectrotemporal correlations
    Michael J. Jaroszewicz
    Mengxiao Liu
    Jihyun Kim
    Guannan Zhang
    Yaewon Kim
    Christian Hilty
    Lucio Frydman
    Nature Communications, 13
  • [25] Real-Time Monitoring of Organic Reactions with Two-Dimensional Ultrafast TOCSY NMR Spectroscopy
    Herrera, Antonio
    Fernandez-Valle, Encarnacion
    Martinez-Alvarez, Roberto
    Molero, Dolores
    Pardo, Zulay D.
    Saez, Elena
    Gal, Maayan
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2009, 48 (34) : 6274 - 6277
  • [26] Real-time monitoring of enzyme-assisted animal protein hydrolysis by NMR spectroscopy - An NMR reactomics concept
    Sundekilde, Ulrik K.
    Jarno, Lise
    Eggers, Nina
    Bertram, Hanne Christine
    LWT-FOOD SCIENCE AND TECHNOLOGY, 2018, 95 : 9 - 16
  • [27] ImageDosis: 2D real-time dosimetry system
    Nascimento, L. De Freitas
    Verellen, D.
    Goossens, J.
    Vanhavere, F.
    Akselrod, M.
    RADIOTHERAPY AND ONCOLOGY, 2020, 152 : S354 - S354
  • [28] Real-time monitoring of PEGylation by NMR spectroscopy
    Luo, Ying
    Zhang, Roujian
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U581 - U581
  • [29] Monitoring live mitochondrial metabolism in real-time using NMR spectroscopy
    Nagana Gowda, G. A.
    Pascua, Vadim
    Lusk, John A.
    Hong, Natalie N.
    Guo, Lin
    Dong, Jiyang
    Sweet, Ian R.
    Raftery, Daniel
    MAGNETIC RESONANCE IN CHEMISTRY, 2023, 61 (12) : 718 - 727
  • [30] Toward Mechanistic Understanding of Mechanochemical Reactions Using Real-Time In Situ Monitoring
    Lukin, Stipe
    Germann, Luzia S.
    Friscic, Tomislav
    Halasz, Ivan
    ACCOUNTS OF CHEMICAL RESEARCH, 2022, 55 (09) : 1262 - 1277
12345