Highly Efficient Organocatalyzed Direct Asymmetric Aldol Reactions of Hydroxyacetone and Aldehydes

被引：45

作者：

Wu, Xiaoyu ^{[1
]}

Ma, Zhixiong ^{[2
]}

Ye, Zhengqing ^{[2
]}

Qian, Shan ^{[2
]}

Zhao, Gang ^{[2
]}

机构：

[1] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, Lab Modern Organ Synthet Chem, Shanghai 200032, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2009年 / 351卷 / 1-2期

关键词：

aldehydes; aldol reaction; 1,2-diols; hydroxyacetone; organic catalysis; WATER-COMPATIBLE ORGANOCATALYSTS; DIRECT SYN-ALDOL; UNPRECEDENTED REGIOCONTROL; BIOACTIVE MACROLIDES; L-PROLINE; KETONES; ACID; AMPHIDINOLIDES; STRATEGY; CATALYST;

D O I：

10.1002/adsc.200800558

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Novel organocatalysts derived from L-threonine and L-leucine have been synthesized for catalyzing direct aldol reactions of hydroxycetone and unactivated aliphatic aldehydes with as low as 2 mol% loading of the catalyst, good to excellent yields and excellent enantioselectivities have been achieved for aliphatic aldehydes, whereas aromatic aldehydes yield only moderate enantioselectivities.

引用

页码：158 / 162

页数：5

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