Effects of naloxone on upper airway collapsibility in normal sleeping subjects

被引：12
|
作者：
Meurice, JC [1 ]
Marc, I [1 ]
Series, F [1 ]
机构：
[1] UNIV LAVAL,HOP LAVAL,CTR PNEUMOL,UNITE RECH,ST FOY,PQ G1V 4G5,CANADA
来源：
THORAX | 1996年 / 51卷 / 08期
关键词：
sleep apnoea/hypopnoea syndrome; endorphins; upper airway dilators; sleep fragmentation;
D O I：
10.1136/thx.51.8.851
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Background - To evaluate the possible influence of endorphin release on upper airway collapsibility the effects of naloxone, an opiate receptor antagonist, were measured. Methods - The effects of naloxone on upper airway collapsibility were studied in five normal sleeping men in a pilot study. During a sleep fragmentation night the subjects received either naloxone or a volume matched saline placebo in a double blind crossover design. Critical pressure (Pcrit) was measured during a morning nap following sleep fragmentation. Results - The plasma levels of endorphins increased during sleep fragmentation nights. Pcrit was significantly greater after placebo than after naloxone infusion. Conclusions - Naloxone may reduce upper airway collapsibility in normal sleeping subjects following sleep fragmentation.
引用
收藏
页码：851 / 852
页数：2
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