Metal-Free Catalytic Approach for Allylic C-H Amination Using N-Heterocycles via sp3 C-H Bond Activation

被引：36

作者：

Sun, Jinwei ^{[1
]}

Wang, Yi ^{[1
]}

Pan, Yi ^{[1
]}

机构：

[1] Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 18期

基金：

中国国家自然科学基金;

关键词：

EFFICIENT SYNTHESIS; DEHYDROGENATIVE FUNCTIONALIZATION; ORGANOCATALYTIC AMINATION; ALLYLAMINE DERIVATIVES; COUPLING REACTIONS; TERMINAL ALKENES; SIMPLE OLEFINS; ALKYLATION; OXIDATION; STRATEGY;

D O I：

10.1021/acs.joc.5b01383

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile metal-free synthesis of allylic N-heterocycles has been developed using a TBAI/TBHP oxidation system. This general protocol could be applied for the C-N bond formation of electron-deficient phthalimides, imidazoles, triazoles, and sulfonamides with cyclic and acylic olefins. The practical use of the method is demonstrated by the amidation of functionalized biologically active substrates.

引用

页码：8945 / 8950

页数：6

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