Metal-Free Catalytic Approach for Allylic C-H Amination Using N-Heterocycles via sp3 C-H Bond Activation

被引：36
|
作者：
Sun, Jinwei [1 ]
Wang, Yi [1 ]
Pan, Yi [1 ]
机构：
[1] Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210093, Jiangsu, Peoples R China
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 80卷 / 18期
基金：
中国国家自然科学基金;
关键词：
EFFICIENT SYNTHESIS; DEHYDROGENATIVE FUNCTIONALIZATION; ORGANOCATALYTIC AMINATION; ALLYLAMINE DERIVATIVES; COUPLING REACTIONS; TERMINAL ALKENES; SIMPLE OLEFINS; ALKYLATION; OXIDATION; STRATEGY;
D O I：
10.1021/acs.joc.5b01383
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A versatile metal-free synthesis of allylic N-heterocycles has been developed using a TBAI/TBHP oxidation system. This general protocol could be applied for the C-N bond formation of electron-deficient phthalimides, imidazoles, triazoles, and sulfonamides with cyclic and acylic olefins. The practical use of the method is demonstrated by the amidation of functionalized biologically active substrates.
引用
收藏
页码：8945 / 8950
页数：6
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