Anti-Glycation Effects of Pomegranate (Punica granatum L.) Fruit Extract and Its Components in Vivo and in Vitro

被引：33

作者：

Kumagai, Yuya ^{[1
]}

Nakatani, Sachie ^{[1
]}

Onodera, Hideaki ^{[1
]}

Nagatomo, Akifumi ^{[2
]}

Nishida, Norihisa ^{[2
]}

Matsuura, Yoichi ^{[2
]}

Kobata, Kenji ^{[1
]}

Wada, Masahiro ^{[1
]}

机构：

[1] Josai Univ, Fac Pharmaceut Sci, Dept Pharmaceutial & Hlth Sci, Saitama, Japan

[2] Morishita Jintan Co Ltd, Osaka, Japan

来源：

JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2015年 / 63卷 / 35期

关键词：

advanced glycation end products (AGEs); pomegranate; ellagic acid; punicalagin; diabetes; ELLAGIC ACID; END-PRODUCTS; ELLAGITANNINS; ENDPRODUCTS; CONSUMPTION; FRUCTOSE; GLUCOSE; AGENT;

D O I：

10.1021/acs.jafc.5b02766

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

Accumulation of advanced glycation end products (AGEs) leads to various diseases such as diabetic complications and arteriosclerosis. In this study, we examined the effect of pomegranate fruit extract (PFE) and its constituent polyphenols on AGE formation in vivo and in vitro. PFE, fed with a high-fat and high-sucrose (HFS) diet to KK-A(y) mice, significantly reduced glycation products such as glycoalbumin (22.0 +/- 2.4%), hemoglobin A1c (5.84 +/- 0.23%), and serum AGEs (8.22 +/- 0.17 mu g/ mL), as compared to a control HFS group (30.6 +/- 2.6%, 7.45 +/- 0.12%, and 9.55 +/- 0.17 mu g/mL, respectively, P < 0.05). In antiglycation assays, PFE, punicalin, punicalagin, ellagic acid, and gallic acid suppressed the formation of AGEs from bovine serum albumin and sugars. In this study, we discuss the mechanism of the antiglycation effects of PFE and its components in vivo and in vitro.

引用

页码：7760 / 7764

页数：5

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