Trovafloxacin in treatment of rabbits with experimental meningitis caused by high-level penicillin-resistant Streptococcus pneumoniae

被引：38
|
作者：
Kim, YS
Liu, QX
Chow, LL
Tauber, MG
机构：
[1] UNIV CALIF SAN FRANCISCO, SAN FRANCISCO GEN HOSP, INFECT DIS LAB, SAN FRANCISCO, CA 94143 USA
[2] UNIV CALIF SAN FRANCISCO, DEPT MED, SAN FRANCISCO, CA 94143 USA
[3] UNIV CALIF SAN FRANCISCO, DEPT NEUROL, SAN FRANCISCO, CA 94143 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1997年 / 41卷 / 05期
关键词：
D O I：
10.1128/AAC.41.5.1186
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The fluoroquinolone trovafloxacin was bactericidal (0.47 +/- 0.23 Delta log(10) CFU/ml h after 10 mg/kg of body weight and 0.78 +/- 0.15 Delta log(10) CFU/ml h after 30 mg/kg) in the treatment of experimental meningitis caused by a highly penicillin-resistant (MlC and minimum bactericidal concentration = 4 and 4 mu g/ml) strain of Streptococcus pneumoniae. Combinations with ampicillin and rifampin were indifferent compared to single drugs.
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页码：1186 / 1189
页数：4
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