Synthesis, Crystal Structure and Biological activity of N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide

被引：0
|
作者：
Tong, Jian-Ying [1 ]
Sun, Na-Bo [1 ]
Wu, Hong-Ke [2 ]
Liu, Xing-Hai [2 ]
机构：
[1] Zhejiang Shuren Univ, Coll Biol & Environm Engn, Hangzhou 310015, Zhejiang, Peoples R China
[2] Zhejiang Univ Technol, Coll Chem Engn & Mat Sci, Hangzhou 310014, Zhejiang, Peoples R China
来源：
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN | 2013年 / 35卷 / 05期
基金：
中国国家自然科学基金;
关键词：
Crystal structure; synthesis; 1,3,4-thiadiazole; herbicidal activity; fungicidal activity; METAL-COMPLEXES; DERIVATIVES; MOIETY;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new 1, 3, 4-thiadiazole compound, N-(5-(o-tolyl)-1,3,4-thiadiazol-2-yl) cyclopropanecarboxamide, was synthesized and its structure was confirmed by H-1 NMR, MS and HRMS. The single crystal structure of the title compound was determined by X-ray diffraction. The preliminary biological test showed that the synthesized compound has moderate herbicidal activity against Brassica campestris and fungicidal activities against Sclerotinia sclerotiorum(Lib.) de Bary, Rhizoctonia solanii, Fusarium oxysporum, Corynespora cassiicola, and Botrytis cinerea.
引用
收藏
页码：1349 / 1353
页数：5
相关论文
共 50 条
  • [11] Synthesis,Crystal Structure and Biological Activity of N-(2,6-Difluorobenzoyl)-N'-[5-(4-trifluoromethyl-phenyl)-1,3,4-thiadiazol-2-yl]ure
    邵宇
    杨平
    李世荣
    王发松
    胡卫兵
    Chinese Journal of Structural Chemistry, 2011, (06) : 848 - 852
  • [12] Synthesis and antibacterial activity of N-[5-(chlorobenzylthio)-1,3,4-thiadiazol-2-yl] piperazinyl quinolone derivatives
    Foroumadi, Alireza
    Firoozpour, Loghman
    Emami, Saeed
    Mansouri, Shahla
    Ebrahimabadi, Abdolrasoul H.
    Asadipour, Ali
    Amini, Mohsen
    Saeid-Adel, Nosratollah
    Shafiee, Abbas
    ARCHIVES OF PHARMACAL RESEARCH, 2007, 30 (02) : 138 - 145
  • [13] Synthesis and acaricidal activity of N-(1,3,4-thiadiazol-2-yl)cyclopropanecarboxamides
    Shiga, Y
    Okada, I
    Fukuchi, T
    JOURNAL OF PESTICIDE SCIENCE, 2003, 28 (01): : 61 - 63
  • [14] Synthesis and acaricidal activity of N-(1,3,4-thiadiazol-2-yl)carboxamides
    Shiga, Y
    Okada, I
    Fukuchi, T
    JOURNAL OF PESTICIDE SCIENCE, 2003, 28 (01): : 58 - 60
  • [15] Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives
    Foroumadi, A
    Emami, S
    Hassanzadeh, AO
    Rapaee, M
    Sokhanvar, K
    Moshafi, MH
    Shafiee, A
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (20) : 4488 - 4492
  • [16] 2-(o-tolyloxy)-N-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]acetamide
    Zhan, Jun-Yan
    Xiong, De-Jun
    Wang, Yan-Gang
    Li, Hai-Bing
    ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS, 2007, 63 : O2184 - O2185
  • [17] Synthesis, crystal structure and bioactivities of N-(2,6-difluorobenzoyl)-N′-[5-(pyrid-4-yl)-1,3,4-thiadiazol-2-yl]urea
    Song, Xin-Jian
    Tan, Xiao-Hong
    Wang, Yan-Gang
    JOURNAL OF CHEMICAL CRYSTALLOGRAPHY, 2008, 38 (06) : 479 - 482
  • [18] Synthesis, Crystal Structure and Bioactivities of N-(2,6-Difluorobenzoyl)-N′-[5-(Pyrid-4-yl)-1,3,4-Thiadiazol-2-yl]Urea
    Xin-Jian Song
    Xiao-Hong Tan
    Yan-Gang Wang
    Journal of Chemical Crystallography, 2008, 38 : 479 - 482
  • [19] Synthesis, Crystal Structure and Antitumor Activity of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N?-((E)-styryl)ureas
    宋新建
    王旭梅
    孙琦
    黄生田
    王艳
    ChineseJournalofStructuralChemistry, 2019, 38 (07) : 1086 - 1092
  • [20] Synthesis, Crystal Structure and Antitumor Activity of N-(5-Aryl-1,3,4-thiadiazol-2-yl)-N′-((E)-styryl)ureas
    Song Xin-Jian
    Wang Xu-Mei
    Sun Qi
    Huang Sheng-Tian
    Wang Yan
    CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2019, 38 (07) : 1086 - 1092
12345