Genetic diversity of HLA system in two populations from Tlaxcala, Mexico: Tlaxcala city and rural Tlaxcala

被引：1

作者：

de los Angeles Pavon-Vargas, Maria ^{[1
]}

Crawford, Michael H. ^{[2
]}

Barquera, Rodrigo ^{[3
,4
]}

Lopez-Gil, Concepcion ^{[1
]}

Arrieta-Bolanos, Esteban ^{[5
]}

Clayton, Stephen ^{[3
]}

Iraiz Hernandez-Zaragoza, Diana ^{[4
,6
]}

Bravo-Acevedo, Alicia ^{[7
]}

del Rocio Ramos-de la Cruz, Flor ^{[1
]}

Mendez-Mani, Patricia ^{[1
]}

Zuniga, Joaquin ^{[8
,9
]}

Yunis, Edmond J. ^{[10
]}

Bekker-Mendez, Carolina ^{[11
]}

Granados, Julio ^{[12
,13
]}

机构：

[1] Inst Mexicano Seguro Social IMSS, Histocompatibil Lab, Unidad Med Alta Especialidad UMAE 6, Puebla, Mexico

[2] Univ Kansas, Lab Biol Anthropol, Lawrence, KS 66045 USA

[3] Max Planck Inst Sci Human Hist, Dept Archaeogenet, Kahlaische Str 10, D-07745 Jena, Germany

[4] Escuela Nacl Antropol & Hist ENAH, Mol Genet Lab, Mexico City, DF, Mexico

[5] Univ Hosp Essen, Inst Expt Cellular Therapy, Essen, Germany

[6] Tecn Genet Aplicadas Clin TGAC, Immunogenet Unit, Mexico City, DF, Mexico

[7] UMAE Hosp Gineco Obstet 4 Luis Castelazo Ayala, Inst Mexicano Seguro Social IMSS, Blood Bank, Mexico City, DF, Mexico

[8] Inst Nacl Enfermedades Resp Ismael Cosio Villegas, Lab Immunobiol & Genet, Mexico City, DF, Mexico

[9] Tecnol Monterrey, Escuela Med & Ciencias Salud, Mexico City, DF, Mexico

[10] Dana Farber Canc Inst, Dept Canc Immunol & Virol, 44 Binney St 1234, Boston, MA 02115 USA

[11] Inst Mexicano Seguro Social IMSS, Ctr Med Nacl La Raza, Infectol Hosp, Immunol & Infectol Res Unit, Calzada Vallejo Y Jacarandas S-N Colonia La Raza, Mexico City 02990, DF, Mexico

[12] Inst Nacl Ciencias Med & Nutr Salvador Zubiran IN, Dept Transplantat, Mexico City, DF, Mexico

[13] Inst Nacl Ciencias Med & Nutr Salvador Zubiran IN, Dept Transplantat, Vasco de Quiroga 15,Belisario Dominguez Secc 16, Tlalpan 14080, Cdmx, Mexico

来源：

HUMAN IMMUNOLOGY | 2020年 / 81卷 / 09期

关键词：

HLA; Immunogenetics; Population genetics; Tlaxcala; Admixture; ADMIXTURE;

D O I：

10.1016/j.humimm.2019.07.282

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1011 Mexicans from the state of Tlaxcala residing in the city of Tlaxcala (N = 181) and rural communities (N = 830), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in Tlaxcala are all of Native American origin. Admixture estimates revealed that the main genetic components are Native American (75.13 +/- 1.56% by ML; 69.24% based on of Native American haplotypes) and European (16.10 +/- 4.98% by ML; 19.74% of European haplotypes), with a less prominent African genetic component (8.78 +/- 4.09% by ML; 4.35% of African haplotypes).

引用

页码：544 / 546

页数：3

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