Restoration of DAP Kinase Tumor Suppressor Function: A Therapeutic Strategy to Selectively Induce Apoptosis in Cancer Cells Using Immunokinase Fusion Proteins

被引：12

作者：

Tur, Mehmet Kemal ^{[1
]}

Daramola, Adebukola K. ^{[2
]}

Gattenloehner, Stefan ^{[1
]}

Herling, Marco ^{[3
,4
,5
]}

Chetty, Shivan ^{[2
]}

Barth, Stefan ^{[2
]}

机构：

[1] Justus Liebig Univ, Univ Hosp, Inst Pathol, D-35390 Giessen, Germany

[2] Univ Cape Town, Canc Biotechnol, Inst Infect Dis & Mol Med, Dept Integrat Biomed Sci,Fac Hlth Sci, ZA-7700 Cape Town, South Africa

[3] Univ Cologne, Excellence Cluster Cellular Stress Response & Agi, Lab Lymphocyte Signaling & Oncoproteome, D-50923 Cologne, Germany

[4] Univ Cologne, Ctr Integrated Oncol Koln Bonn, Dept Internal Med 1, D-50923 Cologne, Germany

[5] Univ Cologne, CECAD, D-50923 Cologne, Germany

来源：

BIOMEDICINES | 2017年 / 5卷 / 04期

关键词：

cancer immunotherapy; death-associated protein kinases (DAPk); apoptosis inducers; humanised cytolytic fusion proteins (hCFPs); PROMOTER METHYLATION; DNA METHYLATION; SIGNAL-TRANSDUCTION; COLORECTAL-CANCER; LUNG-CANCER; DEATH; EXPRESSION; GENE; HYPERMETHYLATION; BINDING;

D O I：

10.3390/biomedicines5040059

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Targeted cancer immunotherapy is designed to selectively eliminate tumor cells without harming the surrounding healthy tissues. The death-associated protein kinases (DAPk) are a family of proapoptotic proteins that play a vital role in the regulation of cellular process and have been identified as positive mediators of apoptosis via extrinsic and intrinsic death-regulating signaling pathways. Tumor suppressor activities have been shown for DAPk1 and DAPk2 and they are downregulated in e.g., Hodgkin's (HL) and B cell lymphoma (CLL), respectively. Here, we review a targeted therapeutic approach which involves reconstitution of DAPks by the generation of immunokinase fusion proteins. These recombinant proteins consist of a disease-specific ligand fused to a modified version of DAPk1 or DAPk2. HL was targeted via CD30 and B-CLL via CD22 cell surface antigens.

引用

页数：12

共 32 条

[31] Second mitochondrial-derived activator of caspases (SMAC) mimetic LCL-161 and TNF-related apoptosis-inducing ligand (TRAIL) induce apoptosis through a kinase-independent RIP1 function in sensitive breast cancer cells
Holmgren, Christian
Thornberg, Ellen Sunstrom
Granqvist, Victoria
Larsson, Christer
CELL DEATH DISCOVERY, 2019, 5
[32] HPV plus cervical cancer cells are selectively killed by the combination of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and the cyclin-dependent kinase-9 inhibitor (CDK9i) dinaciclib
Kotlyar, David S.
Greer, Yoshimi E.
Voeller, Donna
Hernandez, Lidia
Annunziata, Christina M.
Lipkowitz, Stanley
CANCER RESEARCH, 2016, 76

← 1 2 3 4 →