Design and Characterization of Fluconazole Loaded Nanosponges Containing Topical Gel Preparation

被引:0
|
作者
Jadhav, Khanderao R. [1 ,2 ]
Pawar, Ashish Y. [2 ,3 ]
Sanap, Ashwini S. [2 ,3 ]
Rathod, Sharayu P. [2 ,3 ]
Malpure, Prashant S. [1 ,2 ]
Bachhav, Rishikesh S. [1 ,2 ]
机构
[1] KCTs RG Sapkal Coll Pharm, Dept Pharmaceut, Nasik, Maharashtra, India
[2] Savitribai Phule Pune Univ, Pune, Maharashtra, India
[3] MGVs Pharm Coll, Dept Pharmaceut, Nasik, Maharashtra, India
来源
INTERNATIONAL JOURNAL OF LIFE SCIENCE AND PHARMA RESEARCH | 2022年 / 12卷 / 05期
关键词
Fluconazole; Nanosponge; Emulsion solvent diffusion; fungal infection; Topical gel; Scanning electron microscopy; DRUG-DELIVERY SYSTEM; IN-VITRO; FORMULATION; HYDROGEL;
D O I
10.22376/ijpbs/lpr.2022.12.5.P85-98
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The main aim and objective of this research was to develop and evaluate Fluconazole loaded nanosponges and formulate them as suitable topical gels for delivering the drug systemically after topical application. Fluconazole (FLZ) is a potent triazole anti fungistatic drug; topical administration of novel Fluconazole resulted in systemic absorption, for improved therapeutic effect and better dispersibility as compared to conventional topical formulation. Fluconazole (FLZ) nanosponges prepared by using emulsion solvent diffusion method to improve topical permeation. Nanosponges were formulated successfully using ethyl cellulose and Eudragit RS 100 as polymer, polyvinyl alcohol as the surfactant, and dichloromethane as solvent. The optimised batch of fluconazole loaded nanosponges used to prepare topical gel using different concentrations of carbopol gel. The prepared nanosponges were evaluated by various tests like production yield, drug entrapment efficiency, FTIR, particle size, zeta potential, SEM study. The entrapment efficiency and production yield were excellent. Based on the entrapment efficiency and production yield,out of ten formulations batches of nanosponges was evaluated and from that batch F3 was optimised.Optimized batch F3 containing FLZ and EC in the ratio of 1:3 showed optimum physicochemical and release characteristics. The optimised batch F3 of ethyl cellulose shows highest entrapment efficiency as 97.97% and production yield as 93.85% resp. A complex Fourier transform infrared (FTIR) study examines the formation in the nanosponge structure. The nanosponges had particle size in the range of 234.95 to 374.26 nm. The Zeta Potential was strong enough to produce stable formulations. The zeta potential of optimised batch nanosponges was found to be 25.05. SEM analysis of optimized batch F3 confirms that nanosponges were spherical in size with a porous and smooth surface. The formulated fluconazole topical gel were characterized for pH, actual drug content, viscosity, spreadability, In -Vitro drug release study. The in -vitro drug release showed maximum drug release of topical gel i.e. 88.34% in 8 hours. The present study demonstrates that, an antifungal drug Fluconazole is formulated in the form of nanosponges topical gel for the antifungal activity and can be best suitable approach in novel drug delivery system than conventional gel. Hence it is concluded that above topical gel formulation of fluconazole loaded nanosponges can be used in treatment of fungal infection.
引用
收藏
页码:85 / 98
页数:14
相关论文
共 50 条
  • [41] Formulation Design and Evaluation of Hydrocortisone-Loaded Nanoemulsion and Nanoemulsion Gel for Topical Delivery
    Annisa, Rahmi
    Mutiah, Roihatul
    Hakim, Abdul
    Rahmaniyah, Delvi Noer Kholida
    INTERNATIONAL CONFERENCE ON BIOLOGY AND APPLIED SCIENCE (ICOBAS), 2019, 2120
  • [42] Formulation and evaluation of microsponge gel for topical delivery of fluconazole for fungal therapy
    Patel N.
    Padia N.
    Vadgama N.
    Raval M.
    Sheth N.
    Journal of Pharmaceutical Investigation, 2016, 46 (3) : 221 - 238
  • [43] Design, Preparation, Characterization and Evaluation of Five Cocrystal Hydrates of Fluconazole with Hydroxybenzoic Acids
    Yu, Hongmei
    Zhang, Baoxi
    Liu, Meiju
    Xing, Wenhui
    Hu, Kun
    Yang, Shiying
    He, Guorong
    Gong, Ningbo
    Du, Guanhua
    Lu, Yang
    PHARMACEUTICS, 2022, 14 (11)
  • [44] Use, Preparation, and Characterization of Copper-Containing Silica Gel
    Ulutan, Sevgi
    Demir, A. Pinar Tuzun
    Balkose, Devrim
    INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 2020, 59 (21) : 9939 - 9949
  • [45] Preparation and characterization of fullerences containing sol-gel glass
    G. Brusatin
    M. Guglielmi
    R. Bozio
    M. Meneghetti
    R. Signorini
    M. Maggini
    G. Scorrano
    M. Prato
    Journal of Sol-Gel Science and Technology, 1997, 8 : 609 - 613
  • [46] Preparation and Characterization of Fullerenes Containing Sol-Gel Glass
    G. Brusatin
    M. Guglielmi
    R. Bozio
    M. Meneghetti
    R. Signorini
    M. Maggini
    G. Scorrano
    M. Prato
    Journal of Sol-Gel Science and Technology, 1997, 8 : 609 - 613
  • [47] Preparation and characterization of fullerenes containing sol-gel glass
    Brusatin, G
    Guglielmi, M
    Bozio, R
    Meneghetti, M
    Signorini, R
    Maggini, M
    Scorrano, G
    Prato, M
    JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY, 1997, 8 (1-3) : 609 - 613
  • [48] Preparation and characterization of sol-gel glasses containing chromium
    Yáñez-Limón, JM
    Pérez-Roblez, JF
    González-Hernández, J
    Zamorano-Ulloa, R
    Ramirez-Rosales, D
    THIN SOLID FILMS, 2000, 373 (1-2) : 184 - 188
  • [49] Fabrication and characterization of nifedipine loaded β-cyclodextrin nanosponges: An in vitro and in vivo evaluation
    Shringirishi, Madhuri
    Mahor, Alok
    Gupta, Rishikesh
    Prajapati, Sunil Kumar
    Bansal, Kuldeep
    Kesharwani, Prashant
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2017, 41 : 344 - 350
  • [50] In-vitro characterization and cytotoxicity study of flutamide loaded cyclodextrin nanosponges
    Allahyari, Saeideh
    Esmailnezhad, Neda
    Valizadeh, Hadi
    Ghorbani, Marjan
    Jelvehgari, Mitra
    Ghazi, Farhood
    Zakeri-Milani, Parvin
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2021, 61