Anti-diabetic activity peptides from albumin against α-glucosidase and α-amylase

被引：185
|
作者：
Yu, Zhipeng [1 ]
Yin, Yongguang [1 ]
Zhao, Wenzhu [1 ]
Liu, Jingbo [1 ]
Chen, Feng [2 ]
机构：
[1] Jilin Univ, Sch Biol & Agr Engn, Changchun 130022, Peoples R China
[2] Clemson Univ, Dept Food Sci & Human Nutr, Clemson, SC 29634 USA
来源：
FOOD CHEMISTRY | 2012年 / 135卷 / 03期
关键词：
Anti-diabetic activity; Peptides; Diabetes; Glucosidase inhibitor; Amylase inhibitor; Hen egg; Albumin; EGG-WHITE; INHIBITORY-ACTIVITIES; BIOACTIVITIES; ANTIOXIDANT; HYDROLYSATE; EXTRACT; LEAVES; CELLS; RATS;
D O I：
10.1016/j.foodchem.2012.06.088
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The objectives of this study were to identify novel peptides from albumin, and to evaluate and validate the anti-diabetic activity of peptides against alpha-glucosidase and alpha-amylase. In the research, albumin hydrolysate was purified and identified, tandem MS was adapted to characterise the amino acid sequences of peptides from the hydrolysate. In addition, anti-diabetic effects of the peptides with alpha-glucosidase and alpha-amylase inhibitory activity have been performed. The present work found eight novel peptides from albumin. Results also suggested that peptide KLPGF had alpha-glucosidase inhibitory activity with an IC50 of 59.5 +/- 5.7 mu mol l(-1) and alpha-amylase inhibitory activity with an IC50 of 120.0 +/- 4.0 mu mol l(-1). In conclusion, the results revealed that the peptide KLPGF was a potential anti-diabetic inhibitor. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2078 / 2085
页数：8
相关论文
共 50 条
  • [31] Anti-diabetic potential of peptides: Future prospects as therapeutic agents
    Marya
    Khan, Haroon
    Nabavi, Seyed Mohammad
    Habtemariam, Solomon
    LIFE SCIENCES, 2018, 193 : 153 - 158
  • [32] Anti-diabetic activity of Holothuria thomasi saponin
    El Barky, Amira R.
    Hussein, Samy A.
    Alm-Eldeen, Abeer A.
    Hafez, Yehia A.
    Mohamed, Tarek M.
    BIOMEDICINE & PHARMACOTHERAPY, 2016, 84 : 1472 - 1487
  • [33] C-glucosidic ellagitannins and galloylated glucoses as potential functional food ingredients with anti-diabetic properties: a study of α-glucosidase and α-amylase inhibition
    Cardullo, Nunzio
    Muccilli, Vera
    Pulvirenti, Luana
    Cornu, Anaelle
    Pouysegu, Laurent
    Deffieux, Denis
    Quideau, Stephane
    Tringali, Corrado
    FOOD CHEMISTRY, 2020, 313
  • [34] In-vitro anti-diabetic activity and in-silico studies of binding energies of palmatine with alpha-amylase, alpha-glucosidase and DPP-IV enzymes
    Okechukwu, Patrick
    Sharma, Mridula
    Tan, Wen Hui
    Chan, Hor Kuan
    Chirara, Kavita
    Gaurav, Anand
    Al-Nema, Mayasah
    PHARMACIA, 2020, 67 (04) : 363 - 371
  • [35] ANTI-DIABETIC ACTIVITY OF BRUGUIERA GYMNORHIZA ROOT
    Singh, Namrata
    Patel, Atul Vikram
    Alok, Shashi
    Kannojia, Pushpendra
    INTERNATIONAL JOURNAL OF PHARMACEUTICAL SCIENCES AND RESEARCH, 2010, 1 (05): : 115 - 119
  • [36] Anti-diabetic activity of Picrorrhiza kurroa extract
    Joy, KL
    Kuttan, R
    JOURNAL OF ETHNOPHARMACOLOGY, 1999, 67 (02) : 143 - 148
  • [37] Investigation of the anti-diabetic nephropathy activity of puerarin
    Zhang, Wen-Feng
    Yang, Yan
    Li, Xin
    Yang, Bo
    He, Pei-Yu
    Zhang, Hong-Yu
    Duan, Ming-Hua
    MATERIALS EXPRESS, 2020, 10 (11) : 1846 - 1853
  • [38] Anti-diabetic activity of Garcinia xanthochymus seeds
    Payamalle S.
    Joseph K.S.
    Bijjaragi S.C.
    Aware C.
    Jadhav J.P.
    Murthy H.N.
    Comparative Clinical Pathology, 2017, 26 (2) : 437 - 446
  • [39] Potential anti-diabetic activity of Bombax ceiba
    Bhavsar, Chetan J.
    Talele, Gokul S.
    BANGLADESH JOURNAL OF PHARMACOLOGY, 2013, 8 (02) : 102 - 106
  • [40] Anti-diabetic activity of flowers of Hibiscus rosasinensis
    Venkatesh, S.
    Thilagavathi, J.
    Sundar, D. Shyam
    FITOTERAPIA, 2008, 79 (02) : 79 - 81
12345