Phosphodiesterase 4 inhibitors as novel anti-inflammatory agents

被引：69
|
作者：
Doherty, AM [1 ]
机构：
[1] Inst Rech Jouveinal Parke Davis, F-94265 Fresnes, France
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 1999年 / 3卷 / 04期
关键词：
D O I：
10.1016/S1367-5931(99)80068-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Preclinical and clinical studies of phosphodiesterase 4 inhibitors have shown that these agents may find utility in a wide range of inflammatory disorders, including asthma, chronic obstructive pulmonary disease, atopic dermatitis, rheumatoid arthritis, multiple sclerosis and various neurological disorders. The future of this class of drugs will depend upon the ability to demonstrate a reasonable safety margin against emesis and other typical phosphodieserase (PDE4) side effects, as well as in identification of the inflammatory disorder(s) most relevant to PDE4 inhibition.
引用
收藏
页码：466 / 473
页数：8
相关论文
共 50 条
  • [41] NOVEL FORMAZANS AS POTENT ANTI-INFLAMMATORY AND ANALGESIC AGENTS
    KALSI, R
    PANDE, K
    BHALLA, TN
    PARMAR, SS
    BARTHWAL, JP
    PHARMACOLOGY, 1988, 37 (04) : 218 - 224
  • [42] SOME NOVEL PYRAZOLONE DERIVATIVES AS ANTI-INFLAMMATORY AGENTS
    FARGHALY, AM
    ELKHWASS, SM
    KHALIL, MA
    SHARABI, FM
    DAABEES, TT
    PHARMAZIE, 1981, 36 (02): : 93 - 95
  • [43] Novel Molecular Targets in the Search for Anti-Inflammatory Agents
    M. Lienhard Schmitz
    Susanne Bacher
    Phytochemistry Reviews, 2005, 4 (1) : 19 - 25
  • [44] NOVEL THIAZOLIDINONES AS POTENT ANTI-INFLAMMATORY AND ANALGESIC AGENTS
    TANDON, M
    KUMAR, P
    PANDE, K
    BHALLA, TN
    BARTHWAL, JP
    PHARMACOLOGY, 1985, 31 (05) : 260 - 267
  • [45] Strigolactones: a plant phytohormone as novel anti-inflammatory agents
    Zheng, Jun-Xia
    Han, Yu-Shui
    Wang, Jin-Cai
    Yang, Hui
    Kong, Hao
    Liu, Kang-Jia
    Chen, Si-Yu
    Chen, Yi-Rui
    Chang, Yi-Qun
    Chen, Wei-Min
    Guo, Jia-Liang
    Sun, Ping-Hua
    MEDCHEMCOMM, 2018, 9 (01) : 181 - 188
  • [46] Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents
    Li, JJ
    Norton, MB
    Reinhard, EJ
    Anderson, GD
    Gregory, SA
    Isakson, PC
    Koboldt, CM
    Masferrer, JL
    Perkins, WE
    Seibert, K
    Zhang, Y
    Zweifel, BS
    Reitz, DB
    JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (09) : 1846 - 1856
  • [47] Quinazolines as novel anti-inflammatory histone deacetylase inhibitors
    Lin, Zhigang
    Murray, Pamela M.
    Ding, Yaoyao
    Denny, William A.
    Ferguson, Lynnette R.
    MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 2010, 690 (1-2) : 81 - 88
  • [48] Novel drug designing approach for dual inhibitors as anti-inflammatory agents: implication of pyridine template
    Pillai, AD
    Rathod, PD
    Franklin, PX
    Patel, M
    Nivsurkar, M
    Vasu, KK
    Padh, H
    Sudarsanam, V
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 301 (01) : 183 - 186
  • [49] Biochemical evaluation of novel thiazolone derivatives as dual α-glucosidase/α-amylase inhibitors, anti-inflammatory agents
    Abdelhamid, Moustafa Salaheldin
    Eraky, Salwa Samy Abdelfattah
    El-Deen, Ibrahim Mohey
    Sophy, Mohamed Ahmed Elian
    FUTURE MEDICINAL CHEMISTRY, 2025, 17 (02) : 209 - 219
  • [50] Novel uses for anti-platelet agents as anti-inflammatory drugs
    Pitchford, S. C.
    BRITISH JOURNAL OF PHARMACOLOGY, 2007, 152 (07) : 987 - 1002
12345