Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral-low grade diploid acinic cell carcinoma of the parotid gland

被引:33
|
作者
Di Palma, S [1 ]
Corletto, V [1 ]
Lavarino, C [1 ]
Birindelli, S [1 ]
Pilotti, S [1 ]
机构
[1] Ist Nazl Studio & Cura Tumori, Div Pathol & Cytopathol, I-20133 Milan, Italy
来源
VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY | 1999年 / 434卷 / 04期
关键词
dedifferentiated acinic cell carcinoma; parotid; ploidy; proliferative activity; TP53-MSI-LOH;
D O I
10.1007/s004280050353
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
A dedifferentiated acinic cell carcinoma (AciCC) of the right parotid gland with lymph node metastases occurred in a 36-year-old woman. The tumour was associated with a bilateral well-differentiated AciCC, The two components of this tumour had different (high and low) proliferative activity measured by Mib-1 and different (aneuploid and diploid) DNA content. De spite the presence of a high-grade component, TP53 mutations, microsatellite instability (MSI) and/or loss of heterozygosity (LOH) at the p53 locus were not detected. Although the follow-up of the patient is very short, the aggressiveness of the tumour is shown by a recurrence in the right parotid within 4 months and by the rapid development of regional metastases.
引用
收藏
页码:361 / 365
页数:5
相关论文
共 50 条
  • [31] Metastasis of acinic cell carcinoma of the parotid gland to the contralateral orbit
    Saleh, TA
    Hakin, KN
    Davidson, MJ
    ARCHIVES OF OPHTHALMOLOGY, 2003, 121 (12) : 1783 - 1786
  • [32] Acinic cell carcinoma of the parotid gland. Case report
    Dabrowski, Jaroslaw
    Pietka, Tomasz
    Przybysz, Jan
    Krzymanski, Grzegorz
    WSPOLCZESNA ONKOLOGIA-CONTEMPORARY ONCOLOGY, 2011, 15 (01): : 47 - 50
  • [33] Acinic cell carcinoma of the parotid gland. Retrospective analysis
    Federspil, PA
    Constantinidis, J
    Karapantzos, I
    Pahl, S
    Markmann, HU
    Iro, H
    HNO, 2001, 49 (10) : 825 - 830
  • [34] ULTRASTRUCTURE OF ACINIC CELL-CARCINOMA OF PAROTID-GLAND
    ERLANDSON, RA
    TANDLER, B
    ARCHIVES OF PATHOLOGY, 1972, 93 (02): : 130 - +
  • [35] Skull Base Involvement by Acinic Cell Carcinoma of the Parotid Gland
    Breen, Joseph T.
    Carlson, Matthew L.
    Link, Michael J.
    Moore, Eric J.
    Neff, Brian A.
    Driscoll, Colin L. W.
    JOURNAL OF NEUROLOGICAL SURGERY PART B-SKULL BASE, 2012, 73 (06) : 371 - 378
  • [36] Metastatic acinic cell carcinoma of the parotid gland to the abdominal wall
    Poutoglidis, Alexandros
    Pateras, Ioannis
    Kokkinou, Vasiliki
    Tziolas, Petros
    JOURNAL OF SURGICAL CASE REPORTS, 2019, (04):
  • [37] Acinic cell carcinoma of the parotid gland: A diagnostic dilemma on cytology
    Sharma, Abhimanyu
    Ahuja, Sana
    Diwaker, Preeti
    Wadhwa, Neelam
    Arora, Vinod Kumar
    MALAYSIAN JOURNAL OF PATHOLOGY, 2019, 41 (02) : 191 - 194
  • [38] ACINIC CELL-CARCINOMA OF THE PAROTID-GLAND IN CHILDREN
    LEVINE, SB
    POTSIC, WP
    INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY, 1986, 11 (03) : 281 - 286
  • [39] Acinic cell carcinoma arising in pleomorphic adenoma of parotid gland
    Miliauskas, JR
    Orell, SR
    CYTOPATHOLOGY, 2000, 11 (05) : 356 - 359
  • [40] BILATERAL ACINIC CELL TUMORS OF THE PAROTID-GLAND
    NUUTINEN, J
    KANSANEN, M
    SYRJANEN, K
    JOURNAL OF LARYNGOLOGY AND OTOLOGY, 1991, 105 (09): : 796 - 798