IL-10 control of dendritic cells in the skin

被引：13
|
作者：
Clausen, Bjorn E. [1 ,2 ]
Girard-Madoux, Mathilde J. H. [1 ]
机构：
[1] Univ Med Ctr, Erasmus MC, Dept Immunol, Rotterdam, Netherlands
[2] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Inst Mol Med, D-55122 Mainz, Germany
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 03期
关键词：
conditional gene targeting; contact hypersensitivity; dendritic cells; immune regulation; interleukin-10; IL-10 receptor signaling; Langerhans cells; skin; CONTACT HYPERSENSITIVITY; LANGERHANS CELLS; INTERLEUKIN-10; RESPONSES; INFLAMMATION;
D O I：
10.4161/onci.23186
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Interleukin-10 (IL-10) is a potent immunomodulatory cytokine, whose cellular targets have not yet been precisely identified. Dendritic cell (DC)-specific IL-10 receptor knockout mice exhibit exaggerated T-cell reactivation in the skin, highlighting a key role of DCs in the maintenance of local immune homeostasis, beyond their classical function as regulators of T-cell priming in lymph nodes.
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页数：3
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