Design of Salecan-containing semi-IPN hydrogel for amoxicillin delivery

被引：62

作者：

Qi, Xiaoliang ^{[1
]}

Wei, Wei ^{[1
]}

Li, Junjian ^{[1
]}

Su, Ting ^{[1
]}

Pan, Xihao ^{[1
]}

Zuo, Gancheng ^{[1
]}

Zhang, Jianfa ^{[1
]}

Dong, Wei ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Ctr Mol Metab, Nanjing 210094, Jiangsu, Peoples R China

来源：

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS | 2017年 / 75卷

基金：

中国国家自然科学基金;

关键词：

Salecan; Amoxicillin; Poly(N-(3-dimethylaminopropyl)acrylamide-co-acrylamide); Hydrogel devices; INJECTABLE HYDROGELS; CONTROLLED-RELEASE; TARGETED DELIVERY; NETWORK; CHITOSAN; PH; ANTIBACTERIAL; ENCAPSULATION; COPOLYMERS; PROTEIN;

D O I：

10.1016/j.msec.2017.02.089

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Salecan is a new linear extracellular p-glucan. The unique structure and beneficial properties of Salecan makes it an appealing material in biomedical applications. In this work, novel drug devices based on Salecan in a hydrogel matrix of poly(N-(3-dimethylaminopropyl)acrylamide-co-acrylamide) (Salecan/PDA) were fabricated via free radical polymerization for controlled release of amoxicillin. It was demonstrated that amoxicillin was efficiently encapsulated into the developed hydrogels and released in a Salecan dose-dependent and pH-sensitive manner. Furthermore, cell toxicity and adhesion assays confirmed that these drug carriers were biocompatible. Altogether, this study opens a new avenue to fabricate hydrogel devices for controlled delivery of drug. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：487 / 494

页数：8

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