Altered Motor-Striatal Plasticity and Cortical Functioning in Patients with Schizophrenia

被引：18
|
作者：
Zhou, Dongsheng [1 ]
Pang, Feng [2 ]
Liu, Shiyan [1 ]
Shen, Ying [3 ]
Liu, Lingjiang [1 ]
Fang, Zezhong [1 ]
Wang, Chuang [4 ]
Hu, Zhenyu [1 ]
Yuan, Ti-Fei [2 ]
机构：
[1] Ningbo Kangning Hosp, Ningbo Key Lab Behav Neurosci, Ningbo 315201, Zhejiang, Peoples R China
[2] Nanjing Normal Univ, Sch Psychol, Nanjing 210097, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Rehabil Med Ctr, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China
[4] Ningbo Univ, Ningbo Key Lab Behav Neurosci, Sch Med, Ningbo 315211, Zhejiang, Peoples R China
来源：
NEUROSCIENCE BULLETIN | 2017年 / 33卷 / 03期
基金：
中国国家自然科学基金;
关键词：
Schizophrenia; Cortical plasticity; Motor learning; human; TRANSCRANIAL MAGNETIC STIMULATION; LONG-TERM POTENTIATION; CORTEX; NEUROPLASTICITY;
D O I：
10.1007/s12264-016-0079-9
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Patients with schizophrenia undergo changes in brain plasticity. In the present study, we characterized motor cortical-striatal plasticity in such patients. Compared with the potentiation following high-frequency repetitive transcranial magnetic stimulation in the control group, the patients demonstrated impaired plasticity of corticostriatal motor-evoked potentials recorded from hand muscles. Notably, the loss of cortical plasticity was correlated with impaired motor learning in a rotary pursuit task. Moreover, the loss of plasticity was correlated with the symptoms of schizophrenia. The results suggest that the progression of schizophrenia is accompanied by altered cortical plasticity and functioning.
引用
收藏
页码：307 / 311
页数：5
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