TGF-b Superfamily Cytokine MIC-1/GDF15 Is a Physiological Appetite and Body Weight Regulator

被引：150

作者：

Tsai, Vicky Wang-Wei ^{[1
,2
]}

Macia, Laurence ^{[3
]}

Johnen, Heiko ^{[1
,2
]}

Kuffner, Tamara ^{[1
,2
]}

Manadhar, Rakesh ^{[1
,2
]}

Jorgensen, Sebastian Beck ^{[4
]}

Lee-Ng, Ka Ki Michelle ^{[1
,2
]}

Zhang, Hong Ping ^{[1
,2
]}

Wu, Liyun ^{[1
,2
]}

Marquis, Christopher Peter ^{[5
]}

Jiang, Lele ^{[1
,2
]}

Husaini, Yasmin ^{[1
,2
]}

Lin, Shu ^{[3
]}

Herzog, Herbert ^{[3
]}

Brown, David A. ^{[1
,2
]}

Sainsbury, Amanda ^{[3
]}

Breit, Samuel N. ^{[1
,2
]}

机构：

[1] St Vincents Hosp, St Vincents Ctr Appl Med Res, Sydney, NSW 2010, Australia

[2] Univ New S Wales, Sydney, NSW, Australia

[3] Garvan Inst Med Res, Neurosci Program, Sydney, NSW, Australia

[4] Novo Nordisk AS, Diabet Res Unit, Malov, Denmark

[5] Univ New S Wales, Sch Biotechnol & Biomol Sci, Sydney, NSW, Australia

来源：

PLOS ONE | 2013年 / 8卷 / 02期

基金：

英国医学研究理事会; 澳大利亚国家健康与医学研究理事会;

关键词：

MACROPHAGE INHIBITORY CYTOKINE-1; GROWTH-DIFFERENTIATION FACTOR-15; BONE MORPHOGENETIC PROTEIN-7; FACTOR-BETA SUPERFAMILY; DIET-INDUCED OBESITY; BROWN ADIPOGENESIS; SERUM; MIC-1; INDIVIDUALS; DIAGNOSIS;

D O I：

10.1371/journal.pone.0055174

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The TGF-b superfamily cytokine MIC-1/GDF15 circulates in all humans and when overproduced in cancer leads to anorexia/cachexia, by direct action on brain feeding centres. In these studies we have examined the role of physiologically relevant levels of MIC-1/GDF15 in the regulation of appetite, body weight and basal metabolic rate. MIC-1/GDF15 gene knockout mice (MIC-1(-/-)) weighed more and had increased adiposity, which was associated with increased spontaneous food intake. Female MIC-1(-/-) mice exhibited some additional alterations in reduced basal energy expenditure and physical activity, possibly owing to the associated decrease in total lean mass. Further, infusion of human recombinant MIC-1/GDF15 sufficient to raise serum levels in MIC-1(-/-) mice to within the normal human range reduced body weight and food intake. Taken together, our findings suggest that MIC-1/GDF15 is involved in the physiological regulation of appetite and energy storage.

引用

页数：10

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