Synthesis of verbenachalcone congeners and their biological assessment against activation of the NGF-mediated neurite outgrowth of PC12D cells' activity

被引：10
|
作者：
Tanabe, T
Ogamino, T
Shimizu, Y
Imoto, M
Nishiyama, S
机构：
[1] Keio Univ, Fac Sci & Technol, Dept Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
[2] Keio Univ, Fac Sci & Technol, Dept Biosci & Informat, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2006年 / 14卷 / 08期
关键词：
Verbena littoralis; verbenachalcone; littorachalcone; anodic oxidation; NGF-mediated neurite outgrowth;
D O I：
10.1016/j.bmc.2005.11.055
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Synthesis of the verbenachalcone derivatives 3-5 involving littorachalcone 2 from diaryl ether 7 enabled an SAR Study of enhancement activity against the NGF-mediated neurite outgrowth from PC12D cells. Littorachalcone 2 and o-deoxyverbenachalcone 5 showed similar activity to that of verbenachalcone 1. (c) 2005 Elsevier Ltd. All rights reserved.
引用
收藏
页码：2753 / 2762
页数：10
相关论文
共 50 条
  • [41] Novel effect of vitamin K1 (phylloquinone) and vitamin K2 (menaquinone) on promoting nerve growth factor-mediated neurite outgrowth from PC12D cells
    Tsang, CK
    Kamei, Y
    NEUROSCIENCE LETTERS, 2002, 323 (01) : 9 - 12
  • [42] RabGEF1/Rabex-5 Regulates TrkA-Mediated Neurite Outgrowth and NMDA-Induced Signaling Activation in NGF-Differentiated PC12 Cells
    Tam, See-Ying
    Lilla, Jennifer N.
    Chen, Ching-Cheng
    Kalesnikoff, Janet
    Tsai, Mindy
    PLOS ONE, 2015, 10 (11):
  • [43] Receptor-like protein tyrosine phosphatase γ (RPTPγ). but not PTPζ/PTPβ, inhibits nerve-growth-factor-induced neurite outgrowth in PC12D cells
    Shintani, T
    Maeda, N
    Noda, M
    DEVELOPMENTAL NEUROSCIENCE, 2001, 23 (01) : 55 - 69
  • [44] Inhibition of the nerve growth factor-induced outgrowth of neurites by trichostatin A requires protein synthesis de novo in PC12D cells
    Sano, M
    Kitajima, S
    BRAIN RESEARCH, 1996, 742 (1-2) : 195 - 202
  • [45] Role of phospholipase D2 activation in high potassium-induced neurite outgrowth via ERK activation in PC12 cells
    Banno, Y.
    Nemoto, S.
    Hara, A.
    Ohguchi, K.
    Nozawa, Y.
    CHEMISTRY AND PHYSICS OF LIPIDS, 2006, 143 (1-2) : 108 - 109
  • [46] Quercetin Stimulates NGF-induced Neurite Outgrowth in PC12 Cells via Activation of Na+/K+/2Cl- Cotransporter
    Nakajima, Ken-ichi
    Niisato, Naomi
    Marunaka, Yoshinori
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2011, 28 (01) : 147 - 156
  • [47] Functional role of CREB activation by A2A adenosine receptors in rescuing the NGF-induced neurite outgrowth impaired by blockage of the MAPK cascade in PC12 cells
    Cheng, H
    Chern, Y
    MOLECULAR BIOLOGY OF THE CELL, 2002, 13 : 124A - 124A
  • [48] Presenilin-1 mutation alters NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells
    Furukawa, KS
    Guo, Q
    Schellenberg, GD
    Mattson, MP
    JOURNAL OF NEUROSCIENCE RESEARCH, 1998, 52 (05) : 618 - 624
  • [49] Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: Isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways
    Phan, Chia-Wei
    Lee, Guan-Serm
    Hong, Sok-Lai
    Wong, Yuin-Teng
    Brkljača, Robert
    Urban, Sylvia
    Abd Malek, Sri Nurestri
    Sabaratnam, Vikineswary
    Food and Function, 2014, 5 (12): : 3160 - 3169
  • [50] Hericium erinaceus (Bull.: Fr) Pers. cultivated under tropical conditions: isolation of hericenones and demonstration of NGF-mediated neurite outgrowth in PC12 cells via MEK/ERK and PI3K-Akt signaling pathways
    Phan, Chia-Wei
    Lee, Guan-Serm
    Hong, Sok-Lai
    Wong, Yuin-Teng
    Brkljaca, Robert
    Urban, Sylvia
    Abd Malek, Sri Nurestri
    Sabaratnam, Vikineswary
    FOOD & FUNCTION, 2014, 5 (12) : 3160 - 3169
12345