Efficient Diastereoselective Synthesis of (2R,3R,4R)-2-Amino-3-hydroxy-4,5-dimethylhexanoic Acid, the Lactone Linkage Unit of Homophymine A

被引：9

作者：

Ohtaka, Junpei ^{[1
]}

Hamajima, Akinari ^{[1
]}

Nemoto, Tetsuhiro ^{[1
]}

Hamada, Yasumasa ^{[1
]}

机构：

[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, Chiba 2608675, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 02期

关键词：

homophymine A; beta-hydroxy-alpha-amino acid; anti-selective asymmetric hydrogenation; Evans' asymmetric alkylation; DYNAMIC KINETIC RESOLUTION; BETA-KETO-ESTERS; SELECTIVE ASYMMETRIC HYDROGENATION; ALPHA-AMINO ACIDS; STEREOSELECTIVE-SYNTHESIS; IRIDIUM COMPLEX; CYCLODEPSIPEPTIDE; CALLIPELTIN; ACYLATION; SPONGE;

D O I：

10.1248/cpb.c12-00944

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

For the total synthesis of novel cyclodepsipeptide homophymine A, (2R,3R,4R)-2-amino-3-hydroxy-4,5-dimethylhexanoic acid was successfully synthesized by Evans' asymmetric alkylation and the anti-selective asymmetric hydrogenation of a chiral alpha-amino-beta-keto ester as the key steps.

引用

页码：245 / 250

页数：6

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