Efficient Diastereoselective Synthesis of (2R,3R,4R)-2-Amino-3-hydroxy-4,5-dimethylhexanoic Acid, the Lactone Linkage Unit of Homophymine A

被引：9
|
作者：
Ohtaka, Junpei [1 ]
Hamajima, Akinari [1 ]
Nemoto, Tetsuhiro [1 ]
Hamada, Yasumasa [1 ]
机构：
[1] Chiba Univ, Grad Sch Pharmaceut Sci, Chuo Ku, Chiba 2608675, Japan
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2013年 / 61卷 / 02期
关键词：
homophymine A; beta-hydroxy-alpha-amino acid; anti-selective asymmetric hydrogenation; Evans' asymmetric alkylation; DYNAMIC KINETIC RESOLUTION; BETA-KETO-ESTERS; SELECTIVE ASYMMETRIC HYDROGENATION; ALPHA-AMINO ACIDS; STEREOSELECTIVE-SYNTHESIS; IRIDIUM COMPLEX; CYCLODEPSIPEPTIDE; CALLIPELTIN; ACYLATION; SPONGE;
D O I：
10.1248/cpb.c12-00944
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
For the total synthesis of novel cyclodepsipeptide homophymine A, (2R,3R,4R)-2-amino-3-hydroxy-4,5-dimethylhexanoic acid was successfully synthesized by Evans' asymmetric alkylation and the anti-selective asymmetric hydrogenation of a chiral alpha-amino-beta-keto ester as the key steps.
引用
收藏
页码：245 / 250
页数：6
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