68Ga-labeled dimeric and trimeric cyclic RGD peptides as potential PET radiotracers for imaging gliomas

被引：9
|
作者：
Zhao, Zuo-Quan [1 ,2 ]
Ji, Shundong [3 ]
Li, Xiao-Yan [4 ]
Fang, Wei [1 ,2 ]
Liu, Shuang [3 ]
机构：
[1] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, Dept Nucl Med, Beijing, Peoples R China
[2] Peking Union Med Coll, Beijing, Peoples R China
[3] Purdue Univ, Sch Hlth Sci, 550 Stadium Mall Dr, W Lafayette, IN 47907 USA
[4] Beijing Normal Univ, Coll Chem, Minist Educ, Key Lab Radiopharmaceut, Beijing 100875, Peoples R China
来源：
APPLIED RADIATION AND ISOTOPES | 2019年 / 148卷
关键词：
Radiotracers; Integrin alpha(v)beta(3); Ga-68-labeled cyclic RGD peptides; Glioma imaging; IMPROVING TUMOR UPTAKE; INTEGRIN ALPHA(V)BETA(3); BIOLOGICAL-PROPERTIES; EXCRETION KINETICS; F-18-ALFATIDE II; LUNG-CANCER; GLIOBLASTOMA; CILENGITIDE; EXPRESSION; LINKER;
D O I：
10.1016/j.apradiso.2019.03.033
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Ga-68-labeled cyclic RGD dimers and trimer were evaluated as PET radiotracers. It was found that the linker group had little impact on alpha(v)beta(3) binding affinity of RGD dimers, which share similar alpha(v)beta(3) binding affinity with the RGD trimer despite of their different multiplicity. Biodistribution properties of Ga-68 radiotracers depend on RGD peptides and radiometal chelates. Among the Ga-68 radiotracers evaluated, Ga-68-I2P-RGD(2) has the best tumor uptake with good tumor-to-background ratios, and is a good PET radiotracer for imaging gliomas.
引用
收藏
页码：168 / 177
页数：10
相关论文
共 50 条
  • [21] Evaluation of 68Ga-labeled RGD peptides for αvβ3 integrin detection in myocardial infarct
    Laitinen, Iina
    Pohle, Karolin
    Notni, Johannes
    Rudelius, Martina
    Weidl, Eliane
    Henriksen, Gjermund
    Wester, Hans
    Schwaiger, Markus
    JOURNAL OF NUCLEAR MEDICINE, 2012, 53
  • [22] Infrared-based module for the synthesis of 68Ga-labeled radiotracers
    Azhdarinia, Ali
    Yang, David J.
    Chao, Clifford
    Mourtada, Firas
    NUCLEAR MEDICINE AND BIOLOGY, 2007, 34 (01) : 121 - 127
  • [23] 68Ga-labeled Ciprofloxacin Conjugates as Radiotracers for Targeting Bacterial Infection
    Satpati, Drishty
    Arjun, Chanda
    Krishnamohan, Repaka
    Samuel, Grace
    Banerjee, Sharmila
    CHEMICAL BIOLOGY & DRUG DESIGN, 2016, 87 (05) : 680 - 686
  • [24] A 68Ga-labeled linear peptide-based PET radiotracers for imaging PD-L1 status in tumors
    Hu, Kuan
    Zhang, Siqi
    Zhang, Lulu
    Wang, Xingkai
    Shen, Jieting
    Xie, Lin
    Zhang, Ming-Rong
    NUCLEAR MEDICINE AND BIOLOGY, 2023, 126 : S153 - S153
  • [25] 68Ga-labeled peptide-based PET radiotracers for imaging PD-L2 expression in lung cancer
    Zhou, M.
    Hu, S.
    EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, 2024, 51 : S950 - S951
  • [26] Synthesis and Characterization of 68Ga-Labeled Curcumin and Curcuminoid Complexes as Potential Radiotracers for Imaging of Cancer and Alzheimer's Disease
    Asti, Mattia
    Ferrari, Erika
    Croci, Stefania
    Atti, Giulia
    Rubagotti, Sara
    Iori, Michele
    Capponi, Pier C.
    Zerbini, Alessandro
    Saladini, Monica
    Versari, Annibale
    INORGANIC CHEMISTRY, 2014, 53 (10) : 4922 - 4933
  • [27] Radiolabeled cyclic RGD peptides as radiotracers for tumor imaging
    Jiyun Shi
    Fan Wang
    Shuang Liu
    BiophysicsReports, 2016, 2 (01) : 1 - 20
  • [28] Cyclic RGD Peptides Incorporating Cycloalkanes: Synthesis and Evaluation as PET Radiotracers for Tumor Imaging
    Park, Ji-Ae
    Lee, Yong Jin
    Lee, Ji Woong
    Lee, Kyo Chul
    An, Gwang Il
    Kim, Kyeong Min
    Kim, Byung Il
    Kim, Tae-Jeong
    Kim, Jung Young
    ACS MEDICINAL CHEMISTRY LETTERS, 2014, 5 (09): : 979 - 982
  • [29] Evaluation of 68Ga-labeled tracers for PET imaging of myocardial perfusion in pigs
    Tarkia, Miikka
    Saraste, Antti
    Saanijoki, Tiina
    Oikonen, Vesa
    Vahasilta, Tommi
    Strandberg, Marjatta
    Stark, Christoffer
    Tolvanen, Tuula
    Teras, Mika
    Savunen, Timo
    Green, Mark A.
    Knuuti, Juhani
    Roivainen, Anne
    NUCLEAR MEDICINE AND BIOLOGY, 2012, 39 (05) : 715 - 723
  • [30] Synthesis and evaluation of a 68Ga-labeled spermine derivative for tumor PET imaging
    Qin, Kaixin
    Shi, Dongmei
    Zheng, Yuzhou
    Hu, Wenhao
    Kang, Xiameng
    Wu, Ping
    Hao, Xinzhong
    Liu, Haiyan
    Gao, Jie
    Li, Jianguo
    Wu, Zhifang
    Li, Sijin
    Wang, Hongliang
    NUCLEAR MEDICINE AND BIOLOGY, 2024, 134
12345