Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole

被引：16

作者：

Honorato, Sara Braga ^{[1
]}

Mendonca, Jorge Souza ^{[2
]}

Boechat, Nubia ^{[2
]}

Oliveira, Alcemira Conceicao ^{[1
]}

Mendes Filho, Josue ^{[1
]}

Ellena, Javier ^{[3
]}

Ayala, Alejandro Pedro ^{[1
]}

机构：

[1] Univ Fed Ceara, Dept Phys, BR-60455760 Fortaleza, Ceara, Brazil

[2] Fundacao Oswaldo Cruz FioCruz, Inst Tecnol Farmacos FarManguinhos, BR-21041250 Rio De Janeiro, Brazil

[3] Univ Sao Paulo, Inst Fis Sao Carlos, BR-13560970 Sao Paulo, Brazil

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2014年 / 118卷

基金：

巴西圣保罗研究基金会;

关键词：

Benznidazole; Polymorphism; Hot stage microscopy; Thermal analysis; X-ray powder diffraction; Infrared spectroscopy; PHYSICOCHEMICAL CHARACTERIZATION; MOLECULAR-CRYSTALS; PHARMACEUTICALS;

D O I：

10.1016/j.saa.2013.08.096

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

Benznidazole (N-benzyl-2-(2-nitro-1H-imidazol-1-yl)acetamide), is a nitro-heterocyclic drug used in the treatment of Chagas disease. Despite the fact that this drug was released more than 30 years ago, little information about its solid state properties is available in the literature. In this study, it was verified that this drug exhibits three polymorphs, which were characterized in situ by X-ray powder diffraction, thermal analysis, hot stage microscopy and infrared spectroscopy. The thermodynamic relationships among these polymorphs were also discussed. (C) 2013 Elsevier B.V. All rights reserved.

引用

页码：389 / 394

页数：6

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