Diffusion tensor imaging in schizophrenia

被引：131

作者：

Kyriakopoulos, Marinos ^{[1
]}

Bargiotas, Theodoros ^{[1
]}

Barker, Gareth J. ^{[2
]}

Frangou, Sophia ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, Neurobiol Sect, London WC2R 2LS, England

[2] Kings Coll London, Ctr Neuroimaging Sci, Inst Psychiat, Dept Clin Neurosci, London, England

来源：

EUROPEAN PSYCHIATRY | 2008年 / 23卷 / 04期

关键词：

schizophrenia; diffusion tensor imaging; white matter; anisotropy; tractography;

D O I：

10.1016/j.eurpsy.2007.12.004

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Diffusion tensor imaging (DTI) is a magnetic resonance imaging technique that is increasingly being used for the non-invasive evaluation of brain white inatter abnormalities. In this review, we discuss the basic principles of DTI, its roots and the contribution of European centres in its development, and we review the findings from DT1 studies in schizophrenia. We searched EMBASE, PUbMed, PsychInfo, and Medline from February 1998 to December 2006 using as keywords 'schizophrenia', 'diffusion', 'tensor', and 'DTF. Forty studies fulfilling the inclusion criteria of this review were included and systematically reviewed. White matter abnormalities in many diverse brain regions were identified in schizophrenia. Although the findings are not completely consistent, frontal and temporal white matter seems to be more commonly affected. Limitations and future directions of this method are discussed. (c) 2008 Published by Elsevier Masson SAS.

引用

页码：255 / 273

页数：19

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