Influence of Usnic Acid and its Derivatives on the Activity of Mammalian Poly(ADP-ribose)polymerase 1 and DNA Polymerase β

被引：12
|
作者：
Zakharenko, Alexandra [2 ]
Sokolov, Dmitry [1 ]
Luzina, Olga [1 ]
Sukhanova, Maria [2 ]
Khodyreva, Svetlana [2 ]
Zakharova, Olga [2 ]
Salakhutdinov, Nariman [1 ]
Lavrik, Olga [2 ]
机构：
[1] Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
[2] Russian Acad Sci, Siberian Branch, Novosibirsk Inst Chem Biol & Fundamental Med, Novosibirsk 630090, Russia
来源：
MEDICINAL CHEMISTRY | 2012年 / 8卷 / 05期
关键词：
DNA Polymerase beta; PARP1; Poly(ADP-ribose)polymerase; Usnic acid; NITRIC-OXIDE SYNTHASE; HUMAN CANCER-CELLS; (+)-USNIC ACID; CHEMICAL-MODIFICATION; CYTOTOXIC ACTIVITY; DIFFRACTAIC ACID; LICHEN COMPOUNDS; IN-VITRO; REPAIR; EXCISION;
D O I：
10.2174/157340612802084225
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The influence of a number of usnic acid derivatives on auto(polyADP-ribosyl)ation catalyzed by PARP1 and DNA synthesis catalyzed by DNA polymerase beta was studied. The derivatives of usnic acid containing aromatic substituents were shown to be moderate inhibitors of PARP1. The presence of both usnic acid tricyclic structure and aromatic substituent at any position of the molecule is a key factor for the inhibitory action. In the case of DNA polymerase, no relationship between the structure and inhibitory properties has been found with the only exception. Derivatives with modified ring A showed mild activation of DNA synthesis catalyzed by DNA polymerase beta.
引用
收藏
页码：883 / 893
页数：11
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