MicroRNAs: Target Recognition and Regulatory Functions

被引：16298
|
作者：
Bartel, David P. [1 ,2 ,3 ]
机构：
[1] MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USA
[2] MIT, Dept Biol, Cambridge, MA 02139 USA
[3] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA
来源：
CELL | 2009年 / 136卷 / 02期
基金：
美国国家卫生研究院;
关键词：
UTR SEQUENCE MOTIF; POSTTRANSCRIPTIONAL REGULATION; MESSENGER-RNAS; C-ELEGANS; GENE-EXPRESSION; BINDING-SITES; K-BOX; LET-7; ACTIVATION; DIFFERENTIATION;
D O I：
10.1016/j.cell.2009.01.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs (miRNAs) are endogenous 23 nt RNAs that play important gene-regulatory roles in animals and plants by pairing to the mRNAs of protein-coding genes to direct their posttranscriptional repression. This review outlines the current understanding of miRNA target recognition in animals and discusses the widespread impact of miRNAs on both the expression and evolution of protein-coding genes.
引用
收藏
页码：215 / 233
页数：19
相关论文
共 50 条
  • [21] Primary transcripts of microRNAs encode regulatory peptidesPrimary transcripts of microRNAs encode regulatory peptides
    Lauressergues, Dominique
    Couzigou, Jean-Malo
    Clemente, Helene San
    Martinez, Yves
    Dunand, Christophe
    Becard, Guillaume
    Combier, Jean-Philippe
    NATURE, 2015, 520 (7545) : 90 - U205
  • [22] Exploring the regulatory roles of MicroRNAs on NF- ΚB target genes in individuals with apical periodontitis
    Alejandra Fernández
    María José Bendek
    María José Bordagaray
    Valeria Ramírez
    Alejandra Chaparro
    Marcela Hernández
    Clinical Oral Investigations, 29 (5)
  • [23] Regulatory MicroRNA Networks: Complex Patterns of Target Pathways for Disease-related and Housekeeping MicroRNAs
    Zafari, Sachli
    Backes, Christina
    Leidinger, Petra
    Meese, Eckart
    Keller, Andreas
    GENOMICS PROTEOMICS & BIOINFORMATICS, 2015, 13 (03) : 159 - 168
  • [24] A putative pathogen-resistant regulatory pathway between MicroRNAs and candidate target genes in maize
    Jian Gao
    Mao Luo
    Chun Zhang
    Hua Peng
    Haijian Lin
    Yaou shen
    Maojun Zhao
    Guangtang Pan
    Zhiming Zhang
    Journal of Plant Biology, 2015, 58 : 211 - 219
  • [25] A Putative Pathogen-resistant Regulatory Pathway between MicroRNAs and Candidate Target Genes in Maize
    Gao, Jian
    Luo, Mao
    Zhang, Chun
    Peng, Hua
    Lin, Haijian
    Shen, Yaou
    Zhao, Maojun
    Pan, Guangtang
    Zhang, Zhiming
    JOURNAL OF PLANT BIOLOGY, 2015, 58 (04) : 211 - 219
  • [26] Construction of short tandem target mimic (STTM) to block the functions of plant and animal microRNAs
    Tang, Guiliang
    Yan, Jun
    Gu, Yiyou
    Qiao, Mengmeng
    Fan, Ruiwen
    Mao, Yiping
    Tang, Xiaoqing
    METHODS, 2012, 58 (02) : 118 - 125
  • [27] MicroRNAs and their regulatory roles in plants
    Jones-Rhoades, Matthew W.
    Bartel, David P.
    Bartel, Bonnie
    ANNUAL REVIEW OF PLANT BIOLOGY, 2006, 57 : 19 - 53
  • [28] MicroRNAs and other regulatory RNAs
    Bartel, D.
    FEBS JOURNAL, 2013, 280 : 31 - 31
  • [29] Regulatory Roles of MicroRNAs in Diabetes
    Feng, Juan
    Xing, Wanli
    Xie, Lan
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (10)
  • [30] Functions of microRNAs in osteoporosis
    Ge, D. -W.
    Wang, W. -W.
    Chen, H. -T.
    Yang, L.
    Cao, X. -J.
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2017, 21 (21) : 4784 - 4789
12345