Molecular Imaging of Chemokine Receptor CXCR4

被引:72
|
作者
Weiss, Ido. D. [1 ]
Jacobson, Orit [2 ]
机构
[1] Hadassah Univ Hosp, Goldyne Savad Inst Gene Therapy, IL-91120 Jerusalem, Israel
[2] Hadassah Hebrew Univ Hosp, Dept Nucl Med, Cyclotron Radiochem Unit, IL-91120 Jerusalem, Israel
来源
THERANOSTICS | 2013年 / 3卷 / 01期
关键词
CXCR4; molecular imaging; diagnostics; cancer; HUMAN CANCER XENOGRAFTS; FACTOR-I; EXPRESSION; PET; TUMOR; CELLS; MICROENVIRONMENT; METASTASIS; INHIBITION; ANTAGONIST;
D O I
10.7150/thno.4835
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
CXCR4 was found to be expressed by many different types of human cancers and its expression has been correlated with tumor aggressiveness, poor prognosis and resistance to chemotherapy. CXCR4 was also shown to contribute to metastatic seeding of organs that express its ligand CXCL12 and support the survival of these cells. These findings suggest that CXCR4 is a potentially attractive therapeutic target, and several antagonists and antibodies for this receptor were developed and are under clinical evaluation. Quantifying CXCR4 expression non-invasively might aid in prognostication as a mean for personalized therapy and post treatment monitoring. Multiple attempts were done over the recent years to develop imaging agents for CXCR4 using different technologies including PET, SPECT, fluorescent and bioluminescence, and will be reviewed in this paper.
引用
收藏
页码:76 / 84
页数:9
相关论文
共 50 条
  • [41] CXC chemokine receptor 4 (CXCR4) blockade in cancer treatment
    Shunshun Bao
    Mohammad Darvishi
    Ali H Amin
    Maysoon T. Al-Haideri
    Indrajit Patra
    Khadisha Kashikova
    Irfan Ahmad
    Fahad Alsaikhan
    Zahraa Haleem Al-qaim
    Moaed E. Al-Gazally
    Bahman Abedi Kiasari
    Bahareh Tavakoli-Far
    Akmal A. Sidikov
    Yasser Fakri Mustafa
    Reza Akhavan-Sigari
    Journal of Cancer Research and Clinical Oncology, 2023, 149 : 7945 - 7968
  • [42] Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development
    Yong-Rui Zou
    Andreas H. Kottmann
    Masahiko Kuroda
    Ichiro Taniuchi
    Dan R. Littman
    Nature, 1998, 393 : 595 - 599
  • [43] The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract
    Tachibana, K
    Hirota, S
    Iizasa, H
    Yoshida, H
    Kawabata, K
    Kataoka, Y
    Kitamura, Y
    Matsushima, K
    Yoshida, N
    Nishikawa, S
    Kishimoto, T
    Nagasawa, T
    NATURE, 1998, 393 (6685) : 591 - 594
  • [44] Mechanism of Peptide Agonist Binding in CXCR4 Chemokine Receptor
    Pawnikar, Shristi
    Miao, Yinglong
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2022, 9
  • [45] The Role of chemokine receptor CXCR4 in breast cancer metastasis
    Mukherjee, Debarati
    Zhao, Jihe
    AMERICAN JOURNAL OF CANCER RESEARCH, 2013, 3 (01): : 46 - 57
  • [46] Expression of the chemokine receptor CXCR4 on lymphocytes of leprosy patients
    Mendonca, V. A.
    Alvim de Melo, G. E. B.
    Araujo, M. G.
    Borges, V. O.
    Costa, R. D.
    Martins-Filho, O. A.
    Teixeira-Carvalho, A.
    Sathler-Avelar, R.
    Teixeira, M. M.
    Teixeira, A. L.
    BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, 2011, 44 (12) : 1256 - 1260
  • [47] Soluble chemokine receptor CXCR4 is present in human sera
    Malvoisin, Etienne
    Livrozet, Jean-Michel
    Makloufi, Djamila
    Vincent, Nadine
    ANALYTICAL BIOCHEMISTRY, 2011, 414 (02) : 202 - 207
  • [48] Targeting of the chemokine receptor CXCR4 in acquired trastuzumab resistance
    Tripahy, D.
    Mukhopadhyay, P.
    Verma, U.
    Mukhopadhyay, C.
    Shelton, J.
    Story, M.
    Ding, L.
    BREAST CANCER RESEARCH AND TREATMENT, 2007, 106 : S32 - S32
  • [50] CXC chemokine receptor 4 (CXCR4) blockade in cancer treatment
    Bao, Shunshun
    Darvishi, Mohammad
    Amin, Ali
    Al-Haideri, Maysoon T.
    Patra, Indrajit
    Kashikova, Khadisha
    Ahmad, Irfan
    Alsaikhan, Fahad
    Al-qaim, Zahraa Haleem
    Al-Gazally, Moaed E.
    Kiasari, Bahman Abedi
    Tavakoli-Far, Bahareh
    Sidikov, Akmal A.
    Mustafa, Yasser Fakri
    Akhavan-Sigari, Reza
    JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2023, 149 (10) : 7945 - 7968