Myeloperoxidase in the neurodegenerative process of Parkinson's disease

被引：15

作者：

Teismann, P. ^{[1
]}

机构：

[1] Univ Aberdeen, Sch Med Sci, Aberdeen AB25 2ZD, Scotland

来源：

DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT | 2014年 / 139卷 / 03期

关键词：

myeloperoxidase; Parkinson's disease; MPTP; neutrophils; Aastrocytes; gliosis; neurodegeneration; OXIDATIVE STRESS; MODEL; ACTIVATION; MICE;

D O I：

10.1055/s-0033-1359907

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Myeloperoxidase (MPO) is a hemoprotein which is involved in the unspecific immune response. In this process hypochloric acid is released. Hypochloric acid can react with lipids and proteins and thus lead to cell damage. We were able to show that MPO, as well as a biomarker for MPO - 3-Chlorotyrosine - are upregulated in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-model of Parkinson's disease as well as in the disease itself. Ablation of MPO resulted in a neuroprotective effect in the MPTP-model. Herein we describe the different function of MPO, and how these can lead to the cellular demise as seen in Parkinson's disease.

引用

页码：99 / 102

页数：4

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