MTORC1/2 and HDAC1/2 inhibition promote tumor response through inhibition of MYC

被引：0
|
作者：
DeStefanis, Rebecca A. [1 ]
Olson, Autumn M. [1 ]
DeZeeuw, Alyssa K. [1 ]
Payne, Susan N. [1 ]
Pasch, Cheri A. [1 ]
Clipson, Linda [1 ]
Deming, Dustin A. [1 ]
机构：
[1] Univ Wisconsin Madison, Madison, WI USA
来源：
CANCER RESEARCH | 2022年 / 82卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
1128
引用
收藏
页数：2
相关论文
共 50 条
  • [41] MTORC1 inhibition drives crinophagic degradation of glucagon
    Rajak, Sangam
    Xie, Sherwin
    Tewari, Archana
    Raza, Sana
    Wu, Yajun
    Bay, Boon-Huat
    Yen, Paul M.
    Sinha, Rohit A.
    MOLECULAR METABOLISM, 2021, 53
  • [42] Effects of mTORC1 inhibition on proteasome activity and levels
    Park, Seo Hyeong
    Choi, Won Hoon
    Lee, Min Jae
    BMB REPORTS, 2022, 55 (04) : 161 - 165
  • [43] Rapamycin Ameliorates Inflammation and Fibrosis in the Early Phase of Cirrhotic Portal Hypertension in Rats through Inhibition of mTORC1 but Not mTORC2
    Wang, Weijie
    Yan, Jiqi
    Wang, Huakai
    Shi, Minmin
    Zhang, Mingjun
    Yang, Weiping
    Peng, Chenghong
    Li, Hongwei
    PLOS ONE, 2014, 9 (01):
  • [44] Inhibition of histone deacetylase 1 (HDAC1) and HDAC2 enhances CRISPR/Cas9 genome editing
    Liu, Bin
    Chen, Siwei
    La Rose, Anouk
    Chen, Deng
    Cao, Fangyuan
    Zwinderman, Martijn
    Kiemel, Dominik
    Aissi, Manon
    Dekker, Frank J.
    Haisma, Hidde J.
    NUCLEIC ACIDS RESEARCH, 2020, 48 (02) : 517 - 532
  • [45] Dual mTORC1/2 Inhibition Sensitizes Testicular Cancer Models to Cisplatin Treatment
    Rosas-Plaza, Ximena
    de Vries, Gerda
    Meersma, Gert Jan
    Suurmeijer, Albert J. H.
    Gietema, Jourik A.
    van Vugt, Marcel A. T. M.
    de Jong, Steven
    MOLECULAR CANCER THERAPEUTICS, 2020, 19 (02) : 590 - 601
  • [46] mTORC1/2 Inhibition Preserves Ovarian Function and Fertility During Genotoxic Chemotherapy
    Goldman, Kara N.
    Chenette, Devon
    Arju, Rezina
    Duncan, Francesca E.
    Keefe, David L.
    Grifo, Jamie A.
    Schneiderb, Robert J.
    OBSTETRICAL & GYNECOLOGICAL SURVEY, 2017, 72 (07) : 415 - 416
  • [47] mTORC1 inhibition for epilepsy in TSC: Feasibility in question
    Sparagana, Steven P.
    NEUROLOGY, 2016, 87 (10) : 974 - 975
  • [48] Selective inhibition of mTORC1/2 or PI3K/mTORC1/2 signaling does not prevent or modify epilepsy in the intrahippocampal kainate mouse model
    Gericke, Birthe
    Brandt, Claudia
    Theilmann, Wiebke
    Welzel, Lisa
    Schidlitzki, Alina
    Twele, Friederike
    Kaczmarek, Edith
    Anjum, Muneeb
    Hillmann, Petra
    Loescher, Wolfgang
    NEUROPHARMACOLOGY, 2020, 162
  • [49] Inhibition of nonalcoholic fatty liver disease in mice by selective inhibition of mTORC1
    Gosis, Bridget S.
    Wada, Shogo
    Thorsheim, Chelsea
    Li, Kristina
    Jung, Sunhee
    Rhoades, Joshua H.
    Yang, Yifan
    Brandimarto, Jeffrey
    Li, Li
    Uehara, Kahealani
    Jang, Cholsoon
    Lanza, Matthew
    Sanford, Nathan B.
    Bornstein, Marc R.
    Jeong, Sunhye
    Titchenell, Paul M.
    Biddinger, Sudha B.
    Arany, Zoltan
    SCIENCE, 2022, 376 (6590) : 264 - +
  • [50] Dual inhibition of mTORC1 and mTORC2 perturbs cytoskeletal organization and impairs endothelial cell elongation
    Tsuji-Tamura, Kiyomi
    Ogawa, Minetaro
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2018, 497 (01) : 326 - 331
12345