Functional Dedifferentiation and Altered Connectivity in Older Adults: Neural Accounts of Cognitive Aging

被引:0
|
作者
Goh, Joshua O. S. [1 ]
机构
[1] Univ Illinois, Beckman Inst, Urbana, IL 61801 USA
来源
AGING AND DISEASE | 2011年 / 2卷 / 01期
关键词
Aging; Dedifferentiation; Connectivity; Functional; Structural; Behavioral; Neuromodulation; Imaging; AGE-RELATED-CHANGES; WHITE-MATTER INTEGRITY; PREDICTS MEMORY PERFORMANCE; DOWN SUPPRESSION DEFICIT; WORKING-MEMORY; BRAIN ACTIVITY; INDIVIDUAL-DIFFERENCES; RECOGNITION MEMORY; DEFAULT-MODE; ENVIRONMENTAL COMPLEXITY;
D O I
暂无
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Aging is associated with myriad changes in behavioral performance and brain structure and function. Given this complex interplay of brain and behavior, two streams of findings are reviewed here that show that aging is generally associated with dedifferentiated neural processes, and also changes in functional connectivity. This article considers an integrated view of how such age-related dedifferentiation of neural function and changes in functional connectivity are related, highlighting some recent findings on differences in small-world architecture in the functional connectivity of young and older adults. These findings suggest that both neural connectivity and the organization of these connections are important determinants of processing efficiency with aging that may be the underlying mechanisms for dedifferentiation. Thus, the evaluation of the neurocognitive effects of aging on functional connectivity provides an alternative framework that captures the behavioral and brain changes that are observed in cognitive aging.
引用
收藏
页码:30 / 48
页数:19
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