Synthesis and biological activity of a potent dual-acting platelet-activating factor and 5-lipoxygenase inhibitor.

被引：0

作者：

Hussoin, MS ^{[1
]}

Biftu, T ^{[1
]}

Cai, X ^{[1
]}

Scannell, RT ^{[1
]}

Grewal, G ^{[1
]}

Young, M ^{[1
]}

Yaeger, D ^{[1
]}

Killian, DB ^{[1
]}

Wypij, D ^{[1
]}

Lobell, R ^{[1
]}

Eckman, J ^{[1
]}

LibertineGraham, L ^{[1
]}

Qian, CG ^{[1
]}

Yeh, CG ^{[1
]}

机构：

[1] CYTOMED INC,CAMBRIDGE,MA 02139

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1996年 / 211卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：205 / MEDI

页数：1

共 50 条

[41] Quinolines as potent 5-lipoxygenase inhibitors:: Synthesis and biological profile of L-746,530
Dubé, D
Blouin, M
Brideau, C
Chan, CC
Desmarais, S
Ethier, D
Falgueyret, JP
Friesen, RW
Girard, M
Girard, Y
Guay, J
Riendeau, D
Tagari, P
Young, RN
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (10) : 1255 - 1260
[42] LACTONE AND CYCLIC ETHER ANALOGS OF PLATELET-ACTIVATING FACTOR - SYNTHESIS AND BIOLOGICAL-ACTIVITIES
MIYAZAKI, H
OHKAWA, N
NAKAMURA, N
ITO, T
SADA, T
OSHIMA, T
KOIKE, H
CHEMICAL & PHARMACEUTICAL BULLETIN, 1989, 37 (09) : 2379 - 2390
[43] THE 5-LIPOXYGENASE PRODUCTS CAN MODULATE THE SYNTHESIS OF PLATELET-ACTIVATING FACTOR (ALKYL-ACETYL GPC) IN CA-IONOPHORE A23187-STIMULATED RAT PERITONEAL-MACROPHAGES
SAITO, H
HIRAI, A
TAMURA, Y
YOSHIDA, S
PROSTAGLANDINS LEUKOTRIENES AND MEDICINE, 1985, 18 (03): : 271 - 286
[44] Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors
Barzen, Sebastian
Roedl, Carmen B.
Lill, Andreas
Steinhilber, Dieter
Stark, Holger
Hofmann, Bettina
BIOORGANIC & MEDICINAL CHEMISTRY, 2012, 20 (11) : 3575 - 3583
[45] Synthesis and biological evaluation of simplified ajudazol derivatives reveal potent 5-lipoxygenase inhibition and considerable apoptotic activity in neuroblastoma cells
Wollnitzke, Philipp
Wagner, Raphael
Afsar, Sumaiya Yasmeen
Werner, Markus
Geschold, Robin
Mueller, Christa E.
Werz, Oliver
van Echten-Deckert, Gerhild
Menche, Dirk
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2023, 94
[46] The effects of 5-lipoxygenase inhibition by zileuton on platelet-activating-factor-induced pulmonary abnormalities in mild asthma
Gómez, FP
Iglesia, R
Roca, J
Barberà, JA
Chung, KF
Rodriguez-Roisin, R
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 157 (05) : 1559 - 1564
[47] Dibenzoxepinone hydroxylamines and hydroxamic acids: Dual inhibitors of cyclooxygenase and 5-lipoxygenase with potent topical antiinflammatory activity
Hamer, RRL
Tegeler, JJ
Kurtz, ES
Allen, RC
Bailey, SC
Elliott, ME
Hellyer, L
Helsley, GC
Przekop, P
Freed, BS
White, J
Martin, LL
JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (01) : 246 - 252
[48] (±)-trans-2-[3-methoxy-4-(4-chlorophenylthioethoxy)-5-(N-methyl-N-hydroxyureidyl)methylphenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran (CMI-392), a potent dual 5-lipoxygenase inhibitor and platelet-activating factor receptor antagonist
Cai, XO
Scannell, RT
Yaeger, D
Hussoin, MS
Killian, DB
Qian, CG
Eckman, J
Hwang, SB
Libertine-Garahan, L
Yeh, CG
Ip, SH
Shen, TY
JOURNAL OF MEDICINAL CHEMISTRY, 1998, 41 (11) : 1970 - 1979
[49] PLATELET-ACTIVATING FACTOR IS A POTENT STIMULUS FOR RENAL PROSTAGLANDIN SYNTHESIS - POSSIBLE SIGNIFICANCE IN UNILATERAL URETERAL OBSTRUCTION
WEISMAN, SM
FELSEN, D
VAUGHAN, ED
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1985, 235 (01): : 10 - 15
[50] BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly
Garscha, Ulrike
Voelker, Susanna
Pace, Simona
Gerstmeier, Jana
Emini, Besa
Liening, Stefanie
Rossi, Antonietta
Weinigel, Christina
Rummler, Silke
Schubert, Ulrich S.
Scriba, Gerhard K. E.
Celikoglu, Ersan
Caliskan, Burcu
Banoglu, Erden
Sautebin, Lidia
Werz, Oliver
BIOCHEMICAL PHARMACOLOGY, 2016, 119 : 17 - 26

← 1 2 3 4 5 →