Neural progenitor cells regulate microglia functions and activity

被引：175

作者：

Mosher, Kira I. ^{[1
,2
]}

Andres, Robert H. ^{[3
]}

Fukuhara, Takeshi ^{[1
]}

Bieri, Gregor ^{[1
,2
]}

Hasegawa-Moriyama, Maiko ^{[1
]}

He, Yingbo ^{[1
]}

Guzman, Raphael ^{[3
]}

Wyss-Coray, Tony ^{[1
,4
]}

机构：

[1] Stanford Univ, Sch Med, Dept Neurol & Neurol Sci, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Neurosci IDP Program, Stanford, CA 94305 USA

[3] Stanford Univ, Med Ctr, Dept Neurosurg, Stanford, CA 94305 USA

[4] Vet Adm Palo Alto Hlth Care Syst, Ctr Tissue Regenerat Repair & Restorat, Palo Alto, CA USA

来源：

NATURE NEUROSCIENCE | 2012年 / 15卷 / 11期

基金：

瑞士国家科学基金会; 美国国家卫生研究院; 美国国家科学基金会;

关键词：

ADULT HIPPOCAMPAL NEUROGENESIS; ENDOTHELIAL GROWTH-FACTOR; RECOVERY; BRAIN;

D O I：

10.1038/nn.3233

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We found mouse neural progenitor cells (NPCs) to have a secretory protein profile distinct from other brain cells and to modulate microglial activation, proliferation and phagocytosis. NPC-derived vascular endothelial growth factor was necessary and sufficient to exert at least some of these effects in mice. Thus, neural precursor cells may not only be shaped by microglia, but also regulate microglia functions and activity.

引用

页码：1485 / 1487

页数：3

共 50 条

[1] Neural progenitor cells regulate microglia functions and activity
Kira I Mosher
Robert H Andres
Takeshi Fukuhara
Gregor Bieri
Maiko Hasegawa-Moriyama
Yingbo He
Raphael Guzman
Tony Wyss-Coray
Nature Neuroscience, 2012, 15 : 1485 - 1487
[2] Reactive oxygen species positively regulate proliferative activity in neural progenitor cells
Yoneyama, M.
Kawada, K.
Ogita, K.
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2008, 18 : S226 - S226
[3] Microglia Negatively Regulate the Proliferation and Neuronal Differentiation of Neural Stem/Progenitor Cells Isolated from Poststroke Mouse Brains
Hirano, Yoshinobu
Nakagomi, Takayuki
Nakano-Doi, Akiko
Kubo, Shuji
Minato, Yusuke
Sawano, Toshinori
Sakagami, Masafumi
Tsuzuki, Kenzo
CELLS, 2023, 12 (16)
[4] MICROGLIA PROGENITOR CELLS AND DEVELOPMENT OF MICROGLIA
RICHARDSON, A
NEUHAUS, J
FEDOROFF, S
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1994, 20 (02) : 183 - 185
[5] Glycine-sensitive NMDA receptors positively regulate proliferative activity in neural progenitor cells
Ogita, K.
Gotoh, Y.
Yoneyama, M.
EUROPEAN NEUROPSYCHOPHARMACOLOGY, 2008, 18 : S225 - S226
[6] Leptin Functions Peripherally to Regulate Differentiation of Mesenchymal Progenitor Cells
Scheller, Erica L.
Song, Junhui
Dishowitz, Michael I.
Soki, Fabiana Naomi
Hankenson, Kurt D.
Krebsbach, Paul H.
STEM CELLS, 2010, 28 (06) : 1071 - 1080
[7] Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex
Benedetta Arnò
Francesca Grassivaro
Chiara Rossi
Andrea Bergamaschi
Valentina Castiglioni
Roberto Furlan
Melanie Greter
Rebecca Favaro
Giancarlo Comi
Burkhard Becher
Gianvito Martino
Luca Muzio
Nature Communications, 5
[8] Neural progenitor cells orchestrate microglia migration and positioning into the developing cortex
Arno, Benedetta
Grassivaro, Francesca
Rossi, Chiara
Bergamaschi, Andrea
Castiglioni, Valentina
Furlan, Roberto
Greter, Melanie
Favaro, Rebecca
Comi, Giancarlo
Becher, Burkhard
Martino, Gianvito
Muzio, Luca
NATURE COMMUNICATIONS, 2014, 5
[9] Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex
Cunningham, Christopher L.
Martinez-Cerdeno, Veronica
Noctor, Stephen C.
JOURNAL OF NEUROSCIENCE, 2013, 33 (10): : 4216 - 4233
[10] Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a
Yizhao Ma
Chunhong Li
Yunlong Huang
Yi Wang
Xiaohuan Xia
Jialin C. Zheng
Cell Communication and Signaling, 17

← 1 2 3 4 5 →