Solid-phase synthesis of 2,4,6-trisubstituted pyridines

被引：35
|
作者：
Chiu, CF [1 ]
Tang, ZL [1 ]
Ellingboe, JW [1 ]
机构：
[1] Wyeth Ayerst Res, Div Chem Sci, Pearl River, NY 10965 USA
来源：
JOURNAL OF COMBINATORIAL CHEMISTRY | 1999年 / 1卷 / 01期
关键词：
D O I：
10.1021/cc980005g
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
A new solid-phase synthesis of 2,4,6-trisubstituted pyridines from hydroxyacetophenones is described. The synthesis includes Claisen-Schmidt and Michael reactions on Wang resin to produce 1,5-diketones, which are then cyclized with ammonium acetate. The pyridine substituents are introduced independently and are derived from readily available, diverse sets of starting materials. The method is suitable for the synthesis of arrays of compounds.
引用
收藏
页码：73 / 77
页数：5
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