Macleayine, a new alkaloid from Macleaya cordata

被引：13

作者：

Sai, Chun-Mei ^{[1
]}

Qin, Ning-Bo ^{[1
]}

Jia, Cui-Cui ^{[1
]}

Li, Da-Hong ^{[1
]}

Wang, Kai-Bo ^{[1
]}

Pei, Yue-Hu ^{[1
]}

Bai, Jiao ^{[1
]}

Li, Zhan-Lin ^{[1
]}

Hua, Hui-Ming ^{[1
]}

机构：

[1] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Peoples R China

来源：

CHINESE CHEMICAL LETTERS | 2016年 / 27卷 / 11期

基金：

中国国家自然科学基金;

关键词：

Macleayine; A natural occurring alkaloid; Quantum chemistry calculations; ECD calculation; Plausible biogenetic pathway; Macleaya cordata; CYTOTOXICITY; SANGUINARINE; FRUITS;

D O I：

10.1016/j.cclet.2016.06.017

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Macleayine (1), a new natural occurring alkaloid with a unique Spiro [furanone-piperidinedione] framework, was isolated from the aerial parts of Macleaya cordata. Its unusual structure was established by extensive spectroscopic analyses, computer-assisted structure elucidation software (ACD/Structure Elucidator), quantum chemistry calculations and ECD calculation. The result of virtual molecular docking predicted the compound can enhance the effects of insulin, and may be used to treat type II diabetes. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

引用

页码：1717 / 1720

页数：4

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