Near Full-Length Genome Identification of a Novel HIV-1 Unique (B/C) Recombinant Isolate in Sichuan, China

被引：2
|
作者：
Wang, Yan [1 ]
Ma, Liying [1 ]
Xu, Weisi [1 ]
Li, Fan [1 ]
Liang, Shu [2 ]
Feng, Yi [1 ]
Shao, Yiming [1 ]
Zhang, Fujie [1 ,3 ,4 ]
机构：
[1] Chinese Ctr Dis Control & Prevent, State Key Lab Infect Dis Prevent & Control, Collaborat Innovat Ctr Diag & Treatment Infect Di, Natl Ctr AIDS STD Control & Prevent,Div Treatment, Beijing, Peoples R China
[2] Sichuan Ctr Dis Control & Prevent, Chengdu, Peoples R China
[3] Capital Med Univ, Beijing Ditan Hosp, Clin & Res Ctr Infect Dis, 8 Jingshun Dongjie, Beijing 100015, Peoples R China
[4] Capital Med Univ, Clin Ctr AIDS, Beijing, Peoples R China
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2016年 / 32卷 / 12期
基金：
中国国家自然科学基金;
关键词：
HIV-1; recombinant; heterosexual; near full-length genome; CIRCULATING RECOMBINANT; YUNNAN;
D O I：
10.1089/aid.2016.0087
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A novel HIV-1 unique recombinant virus (XC2014EU20) was identified. It was isolated from an HIV-positive man who was infected through heterosexual sex in Sichuan, China. The near full-length genome analyses showed that the novel recombinant was composed of three subtype B regions in a subtype C backbone. Different from the other circulating recombinant forms and unique recombinant forms, six recombinant breakpoints of XC2014EU20 with seven fragments were observed in the pol, vpu, and nef genes, respectively. The emergence of B/C recombinant strain indicated the increasing complexity of the HIV-1 epidemic in Sichuan, China.
引用
收藏
页码：1229 / 1233
页数：5
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