This article deals with trends in postsecondary science in the United States. Analysis of the literature indicates that science is undergoing a subtle but steady metamorphosis in higher education as follows: a shift in the research paradigm, the rising tide of commercialism, more stringent human subject research regulations, teaching for a scientific workforce, the instructional technology invasion, pressure to participate in teacher education, ethnic and gender inequalities, a proliferation of research disciplines, and fading public influence. It is time that the university science community comes to the realization that science in higher education, like any other human enterprise, is as good as the people who learn, teach, research, and work in it and, most important, that the future of science depends on how it is used for the welfare all mankind.