Recalcitrant Palmar-Plantar Atopic Dermatitis Successfully Treated with Dupilumab: A Case Series

被引:6
|
作者
Deng, Lin [1 ]
Luo, Yingzhi [1 ]
An, Binyi [2 ]
Su, Ming [1 ]
Sang, Hong [3 ]
Liu, Fang [3 ]
机构
[1] Zhejiang Univ, Affiliated Hangzhou Peoples Hosp 1, Dept Dermatol, Sch Med, Hangzhou 310006, Peoples R China
[2] Nanjing Med Univ, Jinling Hosp, Dept Dermatol, Nanjing 210002, Peoples R China
[3] Nanjing Univ, Jinling Hosp, Dept Dermatol, Med Sch, Nanjing 210002, Peoples R China
来源
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY | 2022年 / 15卷
关键词
atopic dermatitis; dupilumab; palmar-plantar; HAND ECZEMA;
D O I
10.2147/CCID.S383327
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Background: Palmar-plantar atopic dermatitis is a common and debilitating condition with significant diagnostic and management challenges.Case Presentation: The paper presents the successful treatment of dupilumab in five female patients with recalcitrant palmar-plantar atopic dermatitis.Methods: The Hand Eczema Severity Index (HECSI) and the Foot Eczema Severity Index (FECSI), eosinophils and IgE levels were evaluated before and after the treatment.Results: Five recalcitrant palmar-plantar atopic dermatitis patients had substantial responses to dupilumab and the persistent pruritus was soon alleviated during the therapy. By week 16, all patients' palmar-plantar eczema has been almost clear, with significant decrease of HECSI and FECSI. The count of eosinophils and IgE levels returned to normal in all patients.Conclusion: Dupilumab significantly improves disease severity and reduces eosinophils and IgE in refractory palmar-plantar AD patients.
引用
收藏
页码:2421 / 2426
页数:6
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