Polysaccharides from Dioscorea batatas Induce Tumor Necrosis Factor-α Secretion via Toll-like Receptor 4-Mediated Protein Kinase Signaling Pathways

被引：40
|
作者：
Liu, Ju-Yun [3 ]
Yang, Feng-Ling [3 ]
Lu, Chun-Ping [3 ]
Yang, Yu-Liang [3 ]
Wen, Chi-Luan [2 ]
Hua, Kuo-Feng [1 ]
Wu, Shih-Hsiung [3 ]
机构：
[1] China Med Univ, Grad Inst Drug Safety, Taichung, Taiwan
[2] Council Agr, Seed Improvement & Propagat Stn, Taichung 426, Taichung Cty, Taiwan
[3] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2008年 / 56卷 / 21期
关键词：
Discorea batatas; mucopolysaccharides; macrophages; tumor necrosis factor-alpha; Toll-like receptor;
D O I：
10.1021/jf8018722
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
The bioactive polysaccharides (named ZPF1) from yam (Dioscorea batatas) were chemically determined, suggesting repeating beta-1,4-mannan as mainly having a feature of acetylation on C-2-OH and C-3-OH, around 28%. The ZPF1 participated in the stimulation of murine wild-type macrophages predominantly in tumor necrosis factor-alpha (TNF alpha). Toll-like receptor 4 is proved to be one of the cellular receptors in ZPF1-mediated TNF alpha secretion. Reactive oxygen species transmission and P13-kinase are found necessary for regulating TNF alpha secretion by ZPF1 stimulation. Moreover, we found that extracellular signal-regulated kinase 1/2, Jun N-terminal kinase 1/2, and p38 mitogen-activated protein kinase play important roles in the regulation of TNF alpha secretion in ZPF1-stimulated macrophages.
引用
收藏
页码：9892 / 9898
页数：7
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