Relationship between vitamin D receptor BsmI and FokI polymorphisms and anthropometric and biochemical parameters describing metabolic syndrome

被引:97
|
作者
Filus, Alicja [1 ]
Trzmiel, Anna [1 ]
Kuliczkowska-Plaksej, Justyna [1 ]
Tworowska, Urszula [1 ]
Jedrzejuk, Diana [1 ]
Milewicz, Andrzej [1 ]
Medras, Marek [1 ]
机构
[1] Wroclaw Med Univ, Dept Endocrinol Diabet & Isotope Treatment, PL-50367 Wroclaw, Poland
来源
AGING MALE | 2008年 / 11卷 / 03期
关键词
Vitamin D receptor (VDR); BsmI VDR polymorphism; FokI VDR polymorphism; obesity; diabetes mellitus;
D O I
10.1080/13685530802273426
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Introduction. It was found that vitamin D may have a direct effect on adipocyte differentiation and metabolism and might be involved in the glucose regulation of insulin secretion, as suggested from the discovery of a nuclear localization of 1,25-(OH)(2)D-3 in pancreatic islets. In recent years, several polymorphisms in the VDR gene which are able to alter the activity of VDR protein have been described. The BsmI and FokI polymorphisms were described in relation to obesity and type 2 diabetes. The aim of the study was to find whether there are associations between BsmI and FokI polymorphisms and anthropometric (BMI, WHR, BP) and biochemical parameters describing metabolic syndrome. Materials and methods. Studied were 176 randomly selected men aged 25-65 years (mean: 51.99 years) with a mean BMI of 28.06 kg/m(2). Two polymorphisms of the VDR gene (FokI and BsmI) were explored using the PCR-RFLP method. Serum glucose, insulin, total cholesterol, LDL, HDL, and TG were measured using commercially available kits. Results. It was found that BB carriers tend to have higher BMI (29.00 +/- 3.74 versus 26.81 +/- 3.76, p-0.024) and waist circumference (101.79 +/- 10.59 versus 96.23 +/- 10.35, p=0.014) compared with the bb genotypes. Similarly, FF and Ff carriers had higher fasting insulin levels than the ff genotypes (12.30 +/- 10.26 versus 9.76 +/- 5.88, p = 0.001 and 9.76 +/- 5.88 vs. 6.35 +/- 2.64, p = 0.008), and lover cHDL levels in comparison to ff genotypes (52.28 +/- 10.02 versus I P 60.63 +/- 16.58, p = 0.015 and 53.70 +/- 12.03 versus 60.63 +/- 16.58, p = 0.032. Besides these, no significant differences were found. Conclusions. The BsmI VDR polymorphism seems to influence BMI, while the FokI VDR polymorphism appears to affect insulin sensitivity and serum cHDL level.
引用
收藏
页码:134 / 139
页数:6
相关论文
共 50 条
  • [41] FokI and BsmI polymorphisms of the vitamin D receptor gene and bone mineral density in a random Bulgarian population sample
    Ivanova, Jivka
    Doukova, Polet
    Boyanov, Mihail
    Popivanov, Plamen
    ENDOCRINE, 2006, 29 (03) : 413 - 418
  • [42] Association of vitamin D receptor gene variants of BsmI, ApaI and FokI polymorphisms with susceptibility or resistance to pulmonary tuberculosis
    Selvaraj, P
    Chandra, G
    Kurian, SM
    Reetha, AM
    Narayanan, PR
    CURRENT SCIENCE, 2003, 84 (12): : 1564 - 1568
  • [43] FokI and BSMI polymorphisms of the vitamin D receptor gene and bone mineral density in a random Bulgarian population sample
    Ivanova, J. I.
    Doukova, P. D.
    Boyanov, M. B.
    Popivanov, P. P.
    OSTEOPOROSIS INTERNATIONAL, 2006, 17 : S351 - S351
  • [44] Associations of polymorphisms in the vitamin D receptor gene (BsmI and FokI) with bone mineral density in postmenopausal women in Malta
    Vidal, C
    Grima, C
    Brincat, M
    Megally, N
    Xuereb-Anastasi, A
    OSTEOPOROSIS INTERNATIONAL, 2003, 14 (11) : 923 - 928
  • [45] Quantitative assessment of the associations between four polymorphisms (FokI, ApaI, BsmI, TaqI) of vitamin D receptor gene and risk of diabetes mellitus
    Wang, Qijuan
    Xi, Bo
    Reilly, Kathleen Heather
    Liu, Man
    Fu, Maosun
    MOLECULAR BIOLOGY REPORTS, 2012, 39 (10) : 9405 - 9414
  • [46] Correlation between Vitamin D Receptor Gene FOKI and BSMI Polymorphisms and the Susceptibility to Pulmonary Tuberculosis in an Indonesian Batak-ethnic Population
    Sinaga, Bintang Y. M.
    Amin, Muhammad
    Siregar, Yahwardiah
    Sarumpaet, Sori M.
    ACTA MEDICA INDONESIANA, 2014, 46 (04) : 275 - 282
  • [47] Quantitative assessment of the associations between four polymorphisms (FokI, ApaI, BsmI, TaqI) of vitamin D receptor gene and risk of diabetes mellitus
    Qijuan Wang
    Bo Xi
    Kathleen Heather Reilly
    Man Liu
    Maosun Fu
    Molecular Biology Reports, 2012, 39 : 9405 - 9414
  • [48] Association between vitamin D receptor BsmI, FokI, and Cdx2 polymorphisms and osteoporosis risk: an updated meta-analysis
    Chen, Bin
    Zhu, Wang-fa
    Mu, Yi-yang
    Liu, Biao
    Li, Hong-zhuo
    He, Xiao-feng
    BIOSCIENCE REPORTS, 2020, 40
  • [49] Vitamin D and Vitamin D Receptor FokI, ApaI, and BsmI Gene Polymorphisms and their Relation with the Risk of Breast Carcinoma: A Case-control Study
    Dogra, Ashok Kumar
    Prakash, Archana
    Gupta, Sanjay
    Gupta, Meenu
    JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2024, 18 (04) : BC6 - BC11
  • [50] BsmI, TaqI, ApaI and FokI polymorphisms in the vitamin D receptor (VDR) gene and the risk of osteoporosis: A meta-analysis
    Zintzaras, Elias
    Rodopoulou, Paraskevi
    Koukoulis, George N.
    DISEASE MARKERS, 2006, 22 (5-6) : 317 - 326