Design of antineoplastic agents on the basis of the ''2-phenylnaphthalene-type'' structural pattern .3. Synthesis and biological activity evaluation of 5H-benzo[b]naphtho[2,3-d]pyrrole-6,11-dione derivatives

被引:51
|
作者
Luo, YL
Chou, TC
Cheng, CC
机构
[1] UNIV KANSAS,MED CTR,DEPT PHARMACOL TOXICOL & THERAPEUT,KANSAS CITY,KS 66160
[2] MEM SLOAN KETTERING CANC CTR,BIOCHEM PHARMACOL LAB,NEW YORK,NY 10021
关键词
D O I
10.1002/jhet.5570330120
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
A number of 5H-Benzo[b]naphtho[2,3-d]pyrrole-6,11-dione derivatives were synthesized. Their biological activity was compared with that of the corresponding benzoxazolo- and benzthiazolo-analogues.
引用
收藏
页码:113 / 117
页数:5
相关论文
共 50 条
  • [41] Design, synthesis, biological evaluation, homology modeling and docking studies of (E)-3-(benzo[d][1,3]dioxol-5-ylmethylene) pyrrolidin-2-one derivatives as potent anticonvulsant agents
    Wang, Tiantian
    Dong, Shiyang
    Chen, Xiaodong
    Qian, Kun
    Wang, Huayu
    Quan, Hexiu
    Zhang, Zhongli
    Zuo, Yueming
    Huang, Liping
    Li, Dongxun
    Yang, Ming
    Yang, Shilin
    Jin, Yi
    Wang, Zengtao
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2018, 28 (08) : 1324 - 1329
  • [42] Synthesis and biological evaluation of N4-hydrazone derivatives of 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one as novel anticancer agents with antimetastatic adjunct efficacy
    Zhao, Zhichang
    Wang, Hongjun
    Tian, Nana
    Yan, Hong
    Wang, Juan
    ARCHIV DER PHARMAZIE, 2021, 354 (11)
  • [43] New 3-(1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one-based triazole derivatives: Design, synthesis, and biological evaluation as antiproliferative and apoptosis-inducing agents
    Gaikwad, Nikhil B.
    Bansode, Sapana
    Biradar, Shankar
    Ban, Mayuri
    Srinivas, Nanduri
    Godugu, Chandraiah
    Yaddanapudi, Venkata M.
    ARCHIV DER PHARMAZIE, 2021, 354 (11)
  • [44] Synthesis and Biological Evaluation of 12-Aryl-11-hydroxy-5,6-dihydropyrrolo[2",1":3′,4′]pyrazino[1′,2′:1,5]pyrrolo[2,3-d]pyridazine-8(9H)-one Derivatives as Potential Cytotoxic Agents
    Lish, Azam Barghi
    Foroumadi, Alireza
    Kolvari, Eskandar
    Safari, Fatemeh
    ACS OMEGA, 2023, 8 (45): : 42212 - 42224
  • [45] Discovery of 4-(dihydropyridinon-3-yl)amino-5-methylthieno[2,3-d]pyrimidine derivatives as potent Mnk inhibitors: synthesis, structure-activity relationship analysis and biological evaluation
    Yu, Mingfeng
    Li, Peng
    Basnet, Sunita K. C.
    Kumarasiri, Malika
    Diab, Sarah
    Teo, Theodosia
    Albrecht, Hugo
    Wang, Shudong
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2015, 95 : 116 - 126
  • [46] Synthesis and biological studies of novel 2-(4-substitutedbenzylthio)-5-amino-6-(benzo[d] thiazol-2-yl)-7-(4-chlorophenyl)pyrido-[2,3-d]-pyrimidin-4(3H)-one derivatives
    Suresh, M.
    Lavanya, P.
    Raju, K. Naga
    Jonnalagadda, Sreekanth B.
    Rao, C. Venkata
    ORGANIC COMMUNICATIONS, 2011, 4 (02) : 33 - 41
  • [47] Parallel synthesis and biological evaluation of 5,6,7,8-tetrahydrobenzothieno[2,3-d]pyrimidin-4(3H)-one cytotoxic agents selective for p21-deficient cells
    Jennings, LD
    Kincaid, SL
    Wang, YND
    Krishnamurthy, G
    Beyer, CF
    McGinnis, JP
    Miranda, M
    Discafani, CM
    Rabindran, SK
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2005, 15 (21) : 4731 - 4735
  • [48] Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity
    Beyett, Tyler S.
    Gan, Xinmin
    Reilly, Shannon M.
    Gomez, Andrew V.
    Chang, Louise
    Tesmer, John J. G.
    Saltiel, Alan R.
    Showalter, Hollis D.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (20) : 5443 - 5461
  • [49] Design, synthesis, biological evaluation of 6-(2-amino-1H-benzo[d] imidazole-6-yl)quinazolin-4(3H)-one derivatives as novel anticancer agents with Aurora kinase inhibition
    Fan, Chengcheng
    Zhong, Ting
    Yang, Huarong
    Yang, Ying
    Wang, Daoping
    Yang, Xiaosheng
    Xu, Yongnan
    Fan, Yanhua
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 190
  • [50] Design, synthesis and pharmacological evaluation of novel 2-chloro-3-(1H-benzo[d]imidazol-2-yl) quinoline derivatives as antitumor agents: in vitro and in vivo antitumor activity, cell cycle arrest and apoptotic response
    Kuang, Wen-Bin
    Huang, Ri-Zhen
    Fang, Yi-Lin
    Liang, Gui-Bin
    Yang, Chen-Hui
    Ma, Xian-Li
    Zhang, Ye
    RSC ADVANCES, 2018, 8 (43): : 24376 - 24385