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Association of OX40 gene polymorphisms (rs17568G/A and rs229811A/C) with head and neck squamous cell carcinoma
被引:5
|作者:
Faghih, Zahra
[1
]
Abtahi, Shabnam
[2
]
Khademi, Bijan
[3
]
Nikfarjam, Farzaneh
[4
]
Erfani, Nasrollah
[5
,6
]
机构:
[1] Shiraz Univ Med Sci, Shiraz Inst Canc Res, Sch Med, Canc Immunol Grp, Shiraz, Iran
[2] Shiraz Univ Med Sci, Shiraz Inst Canc Res, Sch Med, Shiraz, Iran
[3] Shiraz Univ Med Sci, Sch Med, Dept Otolaryngol, Shiraz, Iran
[4] Shiraz Univ Med Sci, Sch Med, Shiraz, Iran
[5] Shiraz Univ Med Sci, Sch Med, Dept Immunol, POB 71345-1798, Shiraz, Iran
[6] Shiraz Univ Med Sci, Sch Med, Shiraz Inst Canc Res, POB 71345-1798, Shiraz, Iran
关键词:
HNSCC;
CD134;
Gene polymorphisms;
OX40;
rs2298211;
rs17568;
SINONASAL CANCER;
IMMUNITY;
D O I:
10.1007/s11033-019-04602-3
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Head and neck squamous cell carcinoma (HNSCC) is the sixth leading incident cancer worldwide. In this study, we aimed to investigate the possible association of OX40 gene polymorphisms, rs17568G/A and rs229811A/C, with susceptibility to HNSCC and its clinicopathological features. Two hundred and two HNSCC patients and 200 healthy age-sex matched individuals were enrolled. rs17568G/A and rs229811A/C polymorphisms in OX40 gene were genotyped using RFLP-PCR method. We observed more than 2 times increased risk for squamous cell carcinoma development in nose and paranasal sinuses among individuals who inherited GG genotype at rs17568 region (OR 2.29; CI 1.01-5.20; P=0.035). Considering rs2298211 SNP, AA genotype was also observed with higher frequency, in comparison with other two genotypes (AC or CC), among patients with HNSCC originated from these regions (P=0.003). Besides, we observed that patients with C allele at this locus (AC and CC genotypes) have tumors with significantly higher histological grade (P=0.042). Our findings suggest the possible association of rs17568 GG genotype, as well as rs2298211 AA genotype with susceptibility to develop squamous cell carcinoma in the nose and sinonasal cavities.
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页码:2609 / 2616
页数:8
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