A Lewis Acid Palladium(II)-Catalyzed Three-Component Synthesis of α-Substituted Amides

被引：36
|
作者：
Beisel, Tamara [1 ]
Manolikakes, Georg [1 ]
机构：
[1] Goethe Univ Frankfurt, Dept Organ Chem & Chem Biol, D-60054 Frankfurt, Germany
来源：
ORGANIC LETTERS | 2013年 / 15卷 / 23期
关键词：
CATALYZED ASYMMETRIC ARYLATION; N-ACYLIMINIUM IONS; ARYLBORONIC ACIDS; PETASIS REACTION; IMINES; AMINES; DERIVATIVES; ALKYLATION; ALDEHYDES; ALCOHOLS;
D O I：
10.1021/ol402949t
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A Lewis acid palladium-catalyzed reaction of amides, aryl aldehydes, and arylboronic acids is described. This new method allows for a practical and general synthesis of alpha-substituted amides from simple, readily available building blocks.
引用
收藏
页码：6046 / 6049
页数：4
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