QUANTITATIVE SYSTEMS PHARMACOLOGY AS AN ALTERNATIVE TO CHLORPROMAZINE EQUIVALENTS: PREDICTIVE VALIDATION FROM A CRIS DATABASE EXPERIMENT

被引:0
|
作者
Geerts, Hugo [1 ]
Spiros, Athan [1 ]
Kadra, Giouliana [2 ]
Stewart, Robert [2 ]
Hayes, Richard [2 ]
Shetty, Hitesh [3 ]
Iqbal, Ehtesham [4 ]
机构
[1] In Silico Biosci, Lexington, MA USA
[2] Kings Coll London, Inst Psychiat, London, England
[3] South London & Maudsley NHS Fdn Trust, BRC Nucleus, London, England
[4] South London & Maudsley, BRC Nucleus, London, England
关键词
D O I
10.1093/schbul/sby018.1008
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
S221
引用
收藏
页码:S411 / S412
页数:2
相关论文
共 46 条
  • [31] Development and validation of a quantitative systems pharmacology model for prediction of preclinical efficacy of PARP inhibitors rucaparib and talazoparib combined with the ATR inhibitor gartisertib (M4344)
    Villette, Claire C.
    Brightman, Frances
    Dupuy, Nathalie
    Zimmermann, Astrid
    Lignet, Florianne
    Zenke, Frank T.
    Terranova, Nadia
    Bolleddula, Jayaprakasam
    El Bawab, Samer
    Chassagnole, Christophe
    CANCER RESEARCH, 2023, 83 (07)
  • [32] Validation of a method for the detection of virulent Yersinia enterocolitica and their distribution in slaughter pigs from conventional and alternative housing systems
    Nowak, Bernhard
    Von Mueffling, Theda
    Caspari, Kai
    Hartung, Joerg
    VETERINARY MICROBIOLOGY, 2006, 117 (2-4) : 219 - 228
  • [33] Learning from amyloid trials in Alzheimer's disease. A virtual patient analysis using a quantitative systems pharmacology approach
    Geerts, Hugo
    Spiros, Athan
    ALZHEIMERS & DEMENTIA, 2020, 16 (06) : 862 - 872
  • [34] Quantitative Systems Pharmacology Models Predict Optimal Drug Properties and Inform Translation from Mice to Human in Retinal Degenerative Disease
    Lou, Zhen
    Young, Carissa L.
    Hua, Fei
    Savinainen, Anneli
    Apgar, Joshua
    Burke, John
    Welty, Devin
    JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2018, 45 : S30 - S30
  • [35] COMPARATIVE VALIDATION OF QUANTITATIVE CORONARY ANGIOGRAPHY SYSTEMS - RESULTS AND IMPLICATIONS FROM A MULTICENTER STUDY USING A STANDARDIZED APPROACH
    KEANE, D
    HAASE, J
    SLAGER, CJ
    VANSWIJNDREGT, EM
    LEHMANN, KG
    OZAKI, Y
    DIMARIO, C
    KIRKEEIDE, R
    SERRUYS, PW
    CIRCULATION, 1995, 91 (08) : 2174 - 2183
  • [36] From Big Data to Smart Data. How Quantitative Systems Pharmacology Can Support CNS Pharmaceutical R&D
    Geerts, Hugo
    Spiros, Athan
    JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS, 2015, 42 : S25 - S25
  • [37] Alternative arable cropping systems: A key to increase soil organic carbon storage? Results from a 16 year field experiment
    Autret, Benedicte
    Mary, Bruno
    Chenu, Claire
    Balabane, May
    Girardin, Cyril
    Bertrand, Michel
    Grandeau, Gilles
    Beaudoin, Nicolas
    AGRICULTURE ECOSYSTEMS & ENVIRONMENT, 2016, 232 : 150 - 164
  • [38] DEFINITION AND VALIDATION OF A PREDICTIVE MODEL FOR THE IDENTIFICATION OF PATIENTS WITH DISEASES STARTING FROM CHRONIC HEALTH INFORMATION SYSTEMS: THE EXAMPLE OF OBSTRUCTIVE CHRONIC BRONCOPNEUMOPATHY
    Belleudi, V
    Kirchmayer, U.
    Stafoggia, M.
    Bauleo, L.
    Agabiti, N.
    Fusco, D.
    Arca, M.
    Davoli, M.
    Perucci, C. A.
    EPIDEMIOLOGIA & PREVENZIONE, 2010, 34 (5-6): : 186 - 186
  • [39] Predictive value of semi-quantitative MRI-based scoring systems for future knee replacement: data from the osteoarthritis initiative
    Hafezi-Nejad, Nima
    Zikria, Bashir
    Eng, John
    Carrino, John A.
    Demehri, Shadpour
    SKELETAL RADIOLOGY, 2015, 44 (11) : 1655 - 1662
  • [40] Predictive value of semi-quantitative MRI-based scoring systems for future knee replacement: data from the osteoarthritis initiative
    Nima Hafezi-Nejad
    Bashir Zikria
    John Eng
    John A. Carrino
    Shadpour Demehri
    Skeletal Radiology, 2015, 44 : 1655 - 1662