Design, Synthesis and Structure-Activity Relationship Studies of 6-Phenyl-4,5-dihydro-3(2H)-pyridazinone Derivatives as Cardiotonic Agents

被引：0
|
作者：
Wang, Teng [1 ,2 ]
Dong, Ying [1 ,2 ]
Wang, Li-Chen [2 ]
Xiang, Bing-Ren [1 ]
Chen, Zhen [3 ]
Qu, Ling-Bo [4 ]
机构：
[1] China Pharmaceut Univ, Ctr Instrumental Anal, Nanjing 210009, Jiangsu, Peoples R China
[2] China Pharmaceut Univ, Dept Organ Chem, Nanjing 210009, Jiangsu, Peoples R China
[3] China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Jiangsu, Peoples R China
[4] Zhengzhou Univ, Dept Chem, Zhengzhou 450052, Peoples R China
来源：
ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 2008年 / 58卷 / 11期
关键词：
Cardiotonic agents; CAS; 141505-33-1; Levosimendan; 3(2H)-Pyridazinones; cardiotonic activity; structure-activity relationship; synthesis;
D O I：
暂无
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Based on our previous study, a variety of 12 novel 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives were synthesized. The structures attributed to the compounds were elucidated using IR, H-1-NMR and mass spectra. The cardiotonic activities of these compounds were assessed by Straub's perfusion method and a clear cardiotonic effect was shown for compounds 1c (2,3-dichloro-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl) benzamide), id (4-amino-3-methyl-N-(4-(4-methyl6-oxo-1,4,5,6-tetrahydropyridazin-3-yl) phenyl)benzamide), 2a (3-methyl-4-nitro-N-(4-(6-oxo-1,4,5,6-tetrahydro- pyridazin-3-yl)phenyl)benzamide) and 2d (4-amino-3-methyl-N-(4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl) benzamide) when compared to another 3(2H)-pyridazinone derivative, levosimendan (CAS 141505-33-1). The structure-activity relationships of the compounds were studied using the rough sets theory.
引用
收藏
页码：569 / 573
页数：5
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