Design, Synthesis and Structure-Activity Relationship Studies of 6-Phenyl-4,5-dihydro-3(2H)-pyridazinone Derivatives as Cardiotonic Agents

被引：0

作者：

Wang, Teng ^{[1
,2
]}

Dong, Ying ^{[1
,2
]}

Wang, Li-Chen ^{[2
]}

Xiang, Bing-Ren ^{[1
]}

Chen, Zhen ^{[3
]}

Qu, Ling-Bo ^{[4
]}

机构：

[1] China Pharmaceut Univ, Ctr Instrumental Anal, Nanjing 210009, Jiangsu, Peoples R China

[2] China Pharmaceut Univ, Dept Organ Chem, Nanjing 210009, Jiangsu, Peoples R China

[3] China Pharmaceut Univ, Dept Pharmacol, Nanjing 210009, Jiangsu, Peoples R China

[4] Zhengzhou Univ, Dept Chem, Zhengzhou 450052, Peoples R China

来源：

ARZNEIMITTELFORSCHUNG-DRUG RESEARCH | 2008年 / 58卷 / 11期

关键词：

Cardiotonic agents; CAS; 141505-33-1; Levosimendan; 3(2H)-Pyridazinones; cardiotonic activity; structure-activity relationship; synthesis;

D O I：

暂无

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Based on our previous study, a variety of 12 novel 6-phenyl-4,5-dihydro-3(2H)-pyridazinone derivatives were synthesized. The structures attributed to the compounds were elucidated using IR, H-1-NMR and mass spectra. The cardiotonic activities of these compounds were assessed by Straub's perfusion method and a clear cardiotonic effect was shown for compounds 1c (2,3-dichloro-N-(4-(4-methyl-6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl) benzamide), id (4-amino-3-methyl-N-(4-(4-methyl6-oxo-1,4,5,6-tetrahydropyridazin-3-yl) phenyl)benzamide), 2a (3-methyl-4-nitro-N-(4-(6-oxo-1,4,5,6-tetrahydro- pyridazin-3-yl)phenyl)benzamide) and 2d (4-amino-3-methyl-N-(4-(6-oxo-1,4,5,6-tetrahydropyridazin-3-yl)phenyl) benzamide) when compared to another 3(2H)-pyridazinone derivative, levosimendan (CAS 141505-33-1). The structure-activity relationships of the compounds were studied using the rough sets theory.

引用

页码：569 / 573

页数：5

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