SYNTHESIS, ANTIFUNGAL, AND ANTIVIRAL ACTIVITY OF HYDROPHOSPHORYL DERIVATIVES OF MYCOHEPTIN

被引：6
|
作者：
Belakhov, V. V. [1 ]
Shenin, Yu. L. [1 ]
机构：
[1] AOOT Sci Res Technol Inst Antibiot & Med Enzymes, St Petersburg, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2007年 / 41卷 / 06期
关键词：
Antiviral Activity; Macrolide Antibiotic; DMPA; Dermatomycosis; Rous Sarcoma Virus;
D O I：
10.1007/s11094-007-0071-9
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Reactions of the polyene macrolide antibiotic mycoheptin with aldehydes and hypophosphorous acid yielded its hydrophosphoryl derivatives. The physicochemical and biological properties the resulting mycoheptin derivatives were studied. Biological investigations showed that hydrophosphoryl derivatives of mycoheptin were less toxic than the initial antibiotic and had antifungal and antiviral activity.
引用
收藏
页码：314 / 318
页数：5
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