Eremophilane Sesquiterpenes and Polyketones Produced by an Endophytic Guignardia Fungus from the Toxic Plant Gelsemium elegans

被引:33
|
作者
Liu, Yunbao [1 ,2 ]
Li, Yong [1 ,2 ]
Qu, Jing [1 ,2 ]
Ma, Shuanggang [1 ,2 ]
Zang, Caixia [1 ,2 ]
Zhang, Yutian [1 ,2 ]
Yu, Shishan [1 ,2 ]
机构
[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
来源
JOURNAL OF NATURAL PRODUCTS | 2015年 / 78卷 / 09期
基金
中国国家自然科学基金;
关键词
ABSOLUTE-CONFIGURATION; ALKALOIDS; NEUROTOXICITY; DERIVATIVES; SAFFLOWER; EPOXIDES; CURCUMIN; PIGMENT; PETALS; CELLS;
D O I
10.1021/np5009027
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
A cultured endophytic fungus, Guignardia mangiferae, isolated from the toxic plant Gelsemium elegans yielded five new sesquiterpenes (1-5), two new polyketones (6 and 7), and two known terpene polyketones (8 and 9). Their structures were elucidated using spectroscopic methods. On the basis of circular dichroism, the absolute configurations of the new compounds were determined. Compounds 1, 3, 4, and 9 inhibited lipopolysaccharide-induced NO production in BV2 cells with IC50 values of 15.2, 6.4, 4.2, and 4.5 mu M, respectively (positive control curcumin, IC50 = 3.9 mu M).
引用
收藏
页码:2149 / 2154
页数:6
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