Design of macrocyclic serine protease inhibitors using a screen based on enzymatic cyclization.

被引:0
|
作者
Haman, KK [1 ]
Bartlett, P [1 ]
机构
[1] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
380-ORGN
引用
收藏
页码:U127 / U127
页数:1
相关论文
共 50 条
  • [1] Macrocyclic inhibitors for the serine protease plasmin
    Xue, Fengtian
    Seto, Christopher T.
    JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY, 2009, 24 (03) : 779 - 794
  • [2] Macrocyclic inhibitors of the serine protease plasmin: Development and biological activity
    Xue, Fengtian
    Seto, Christoher T.
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2006, 231
  • [3] Macrocyclic Inhibitors Targeting the Prime Site of the Fibrinolytic Serine Protease Plasmin
    Wiedemeyer, Simon J. A.
    Wu, Guojie
    Lang-Henkel, Heike
    Whisstock, James C.
    Law, Ruby H. P.
    Steinmetzer, Torsten
    CHEMMEDCHEM, 2024, 19 (23)
  • [4] DESIGN STRATEGIES FOR SERINE-PROTEASE INHIBITORS
    RIPKA, WC
    FASEB JOURNAL, 1995, 9 (06): : A1253 - A1253
  • [5] Design, synthesis, and testing of macrocyclic β-strand as protease inhibitors
    Pehere, Ashok
    Pietsch, Markus
    Paul, Neilsen
    Callen, David
    Gutschow, Michael
    Abell, Andrew
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 249
  • [6] Mechanism-Based Macrocyclic Inhibitors of Serine Proteases
    Damalanka, Vishnu C.
    Banas, Victoria
    De Bona, Paolo
    Kashipathy, Maithri M.
    Battaile, Kevin
    Lovell, Scott
    Janetka, James W.
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (06) : 4833 - 4854
  • [7] Structure-based design of serine protease inhibitors: The quest for safer and efficacious anticoagulants
    Quan, Mimi
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2015, 249
  • [8] QSAR-BASED MODELLING OF MACROCYCLIC INHIBITORS OF HEPATITIS C VIRUS NS3-4A SERINE PROTEASE
    Srivastava, A. K.
    Pandey, A.
    OXIDATION COMMUNICATIONS, 2011, 34 (01): : 108 - 116
  • [9] Synthesis of macrocyclic, potential protease inhibitors using a generic scaffold
    Dumez, E
    Snaith, JS
    Jackson, RFW
    McElroy, AB
    Overington, J
    Wythes, MJ
    Withka, JM
    McLellan, TJ
    JOURNAL OF ORGANIC CHEMISTRY, 2002, 67 (14): : 4882 - 4892
  • [10] Characterization of the human cytomegalovirus protease as an induced-fit serine protease and the implications to the design of mechanism-based inhibitors
    LaPlante, SR
    Bonneau, PR
    Aubry, N
    Cameron, DR
    Déziel, R
    Grand-Maître, E
    Plouffe, C
    Tong, L
    Kawai, SH
    JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (13) : 2974 - 2986